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Opinion|Videos|December 14, 2023

Encorafenib Plus Binimetinib for BRAF-Mutated Metastatic Melanoma: 7-Year Follow-Up Data From the COLUMBUS Trial

Author(s)Michael Postow, MD, John M. Kirkwood, MD, Meredith McKean, MD, MPH

The 7-year follow-up data for encorafenib/binimetinib showing that around 21% of patients remained progression-free supports BRAF/MEK inhibition as a later treatment option after immunotherapy failure, but doctors are reluctant to stop BRAF/MEK inhibitors given lack of data, even in those patients doing well long-term on the medications with minimal toxicity.

Episodes in this series

EP. 1 The Role of Biomarker Testing in the Management of Metastatic Melanoma

EP. 1 The Role of Biomarker Testing in the Management of Metastatic Melanoma

EP. 2 Best Practices for Biomarker Testing in Metastatic Melanoma

EP. 2 Best Practices for Biomarker Testing in Metastatic Melanoma

EP. 3 Differences Between Community and Academic Settings Regarding Biomarker Testing Practices in Metastatic Melanoma

EP. 3 Differences Between Community and Academic Settings Regarding Biomarker Testing Practices in Metastatic Melanoma

EP. 4 Treatment Options for Patients With Metastatic Melanoma With a BRAF Mutation

EP. 4 Treatment Options for Patients With Metastatic Melanoma With a BRAF Mutation

EP. 5 Factors Influencing Treatment Decision-Making In Patients With BRAF-Mutated Metastatic Melanoma

EP. 5 Factors Influencing Treatment Decision-Making In Patients With BRAF-Mutated Metastatic Melanoma

EP. 6 Frontline Treatment Options for Patients With BRAF-Mutated Metastatic Melanoma

EP. 6 Frontline Treatment Options for Patients With BRAF-Mutated Metastatic Melanoma

EP. 7 Common Adverse Effects Seen With BRAF/MEK Inhibitor Therapy in Patients With BRAF-Mutated Metastatic Melanoma

EP. 7 Common Adverse Effects Seen With BRAF/MEK Inhibitor Therapy in Patients With BRAF-Mutated Metastatic Melanoma

EP. 8 Choosing Between Available Combination BRAF/MEK Inhibitor Options for Patients With BRAF-Mutated Metastatic Melanoma

EP. 8 Choosing Between Available Combination BRAF/MEK Inhibitor Options for Patients With BRAF-Mutated Metastatic Melanoma

EP. 9 Encorafenib Plus Binimetinib for BRAF-Mutated Metastatic Melanoma: 7-Year Follow-Up Data From the COLUMBUS Trial

EP. 9 Encorafenib Plus Binimetinib for BRAF-Mutated Metastatic Melanoma: 7-Year Follow-Up Data From the COLUMBUS Trial

EP. 10 Efficacy and Safety of Rechallenge With BRAF/MEK Inhibitors in Patients With BRAF-Mutated Metastatic Melanoma

EP. 10 Efficacy and Safety of Rechallenge With BRAF/MEK Inhibitors in Patients With BRAF-Mutated Metastatic Melanoma

EP. 11 Treatment Approaches For Patients With BRAF-Mutated Melanoma and Asymptomatic Brain Metastases

EP. 11 Treatment Approaches For Patients With BRAF-Mutated Melanoma and Asymptomatic Brain Metastases

EP. 12 Treatment Approaches For Patients With BRAF-Mutated Melanoma and Symptomatic Brain Metastases

EP. 12 Treatment Approaches For Patients With BRAF-Mutated Melanoma and Symptomatic Brain Metastases

EP. 13 Key Data on Combination Immunotherapies in BRAF-Mutated Melanoma with Brain Metastases

EP. 13 Key Data on Combination Immunotherapies in BRAF-Mutated Melanoma with Brain Metastases

EP. 14 The Future of Metastatic and Unresectable Melanoma Treatment

EP. 14 The Future of Metastatic and Unresectable Melanoma Treatment

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