Experts on the Management of Diarrhea Associated With EGFR TKIs

EP: 1.Emily Skotte, MSN on Rash Management in Patients Treated With EGFR TKIs

EP: 2.Dr. Cass on Managing Diarrhea in Patients Treated With EGFR TKIs

EP: 3.Dr. Piotrowska on the Management of Paronychia Associated With EGFR TKIs

EP: 4.Best Practices for Managing EGFR Tyrosine Kinase Inhibitor–Related Adverse Events

EP: 5.Experts Discuss Management of Skin and Mouth TRAEs Associated With EGFR TKIs

EP: 6.Experts Discuss the Risk of Skin Toxicities Associated With EGFR TKIs

EP: 7.Experts Discuss Common AEs With EGFR TKIs

EP: 8.Experts Discuss the Safety Profile of Mobocertinib in EGFR Exon 20–Mutated Advanced NSCLC

EP: 9.Experts Discuss How to Address Cardiac-Related Toxicities With EGFR TKIs

EP: 10.Experts Discuss the Management of Paronychia When Treating Patients with EGFR TKIs

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EP: 11.Experts on the Management of Diarrhea Associated With EGFR TKIs

Zosia Piotrowska, MD, Jonathan Riess, MD, MS, Gregory Riely, MD, Emily Skotte, MSN, APRN, ACNP-BC, and Amanda Cass, PharmD, BCPS, discuss the management of diarrhea as an adverse effect (AE) associated with EGFR TKIs. 

Zosia Piotrowska, MD, is a clinical researcher and lung cancer medical oncologist, Massachusetts General Hospital Cancer Center. Jonathan Riess, MD, MS, is the medical director of Thoracic Oncology, an associate professor of Medicine, Division of Hematology & Oncology, University of California Davis Comprehensive Cancer Center. Gregory Riely, MD, is a medical oncologist in the Department of Medicine, at Memorial Sloan Kettering Cancer Center. Emily Skotte, MSN, APRN, ACNP-BC, is a nurse practitioner in the Thoracic Oncology Clinic, at Vanderbilt University Medical Center. Amanda Cass, PharmD, BCPS, is a clinical pharmacist, the Thoracic Oncology Clinic, Vanderbilt University Medical Center.

Piotrowska, Riess, Riely, Skotte, and Cass explain that it is important to evaluate patients to determine dietary modification and dietary triggers when they receive treatment with EGFR TKIs. If diarrhea progresses, patients should be treated with loperamide hydrochloride (Imodium), and they should be evaluated for electrolyte and rectal function abnormalities.

An educational discussion with patients prior to treatment will allow them to better understand the risks of diarrhea as an AE. Addressing this AE early on is key to make sure the severity does not progress or worsen during the course of treatment.