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The neoadjuvant/adjuvant pembrolizumab and chemotherapy combination was approved by the FDA in October 2023 for use in this patient population.

Perioperative Pembrolizumab Regimen Upholds Survival Benefit in Resectable NSCLC

Zongertinib demonstrated durable efficacy in patients with pretreated advanced HER2-mutant non–small cell lung cancer.

Zongertinib Elicits Durable Responses in Pretreated Advanced HER2-Mutant NSCLC 

Second-line lenvatinib had clinically meaningful efficacy in patients with advanced HCC after progression on atezolizumab plus bevacizumab.

Lenvatinib Shows Efficacy in Advanced HCC Post-Progression on Atezolizumab/Bevacizumab

The phase 3 TROPiCS-04 study missed its primary end point of improved OS with sacituzumab govitecan vs chemotherapy in patients with urothelial cancer.

Sacituzumab Govitecan Does Not Significantly Improve OS in Pretreated Urothelial Carcinoma

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The FDA awards accelerated approval to encorafenib regimen in BRAF V600E+ CRC, ensartinib wins approval in ALK+ non–small cell lung cancer, and more.

The OncFive: Top Oncology Articles for the Week of 12/15


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Adding dostarlimab to chemotherapy and niraparib maintenance improved progression-free survival in first-line advanced ovarian cancer.

Addition of Dostarlimab to Chemo and Niraparib Maintenance Boosts PFS in Advanced Ovarian Cancer

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The addition of pegcrisantaspase to venetoclax may overcome resistance to prior BCL-2 inhibitor–based regimens for patients with relapsed/refractory AML. 

Venetoclax Plus PegC May Overcome Resistance to Prior BCL-2 Inhibitors in R/R AML 

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Optimizing Intensive Chemotherapy Management in Secondary AML Through Academic Community Collaboration 

Clinical

Video Series

Implementing Updates to AML Classification Guidelines

Video content above is prompted by the following:

Briefly provide an overview of secondary AML.

What is the pathogenesis of this disease?

Please briefly discuss the updates to European LeukemiaNet and World Health Organization classifications for defining secondary AML.

How have the updates to classification guidelines impacted how you diagnose and classify secondary AML patients?

Videos

Margaret Kasner, MD, and Christian Fidler, MD, discuss how effective management of secondary acute myeloid leukemia (AML) in community settings requires early diagnosis, accurate risk stratification, timely referrals, personalized treatment approaches, robust supportive care, and close collaboration with academic centers to ensure optimal patient outcomes.

Panelists discuss how secondary acute myeloid leukemia (AML) presents unique challenges in diagnosis, classification, and treatment due to its complex pathogenesis and evolving classification criteria.

Panelists discuss how secondary acute myeloid leukemia (AML) generally carries a poorer prognosis compared to de novo AML, necessitating careful consideration of treatment goals and open communication with patients about their outlook.

Treatment Goals in Secondary AML

Panelists discuss how comprehensive molecular and cytogenetic testing at diagnosis is crucial for accurate risk stratification, treatment selection, and prognostication in secondary acute myeloid leukemia (AML), while acknowledging the challenges of obtaining timely results, especially in community settings.

The Role of Molecular and Cytogenetic Testing in Secondary AML

Panelists discuss how involving patients and caregivers in the treatment decision-making process for secondary acute myeloid leukemia (AML) requires clear communication, education about options, and consideration of individual values and preferences to ensure informed and shared decision-making.

Patient-Centered Decision-Making in Secondary AML Treatment

Panelists discuss how identifying candidates for allogeneic transplant in secondary acute myeloid leukemia  involves a comprehensive assessment of disease characteristics, patient factors, and timing considerations, while also evaluating fitness for intensive chemotherapy induction using specific criteria to guide treatment decisions.

Assessing Transplant Eligibility and Fitness for Intensive Chemotherapy

Panelists discuss how the NCCN guidelines recommend intensive chemotherapy options, including traditional 7+3 and CPX-351, for newly diagnosed high-risk or secondary AML patients, with treatment selection based on individual patient factors and potential adverse effects.

Evidence-Based Approaches to Intensive Chemotherapy in Secondary AML

Panelists discuss how community settings face unique challenges in delivering intensive chemotherapy regimens for secondary AML, including limited resources and expertise, but can implement best practices and leverage potential benefits of community-based care to provide effective treatment.

Navigating Intensive Chemotherapy in the Community Setting

Panelists discuss how the decision to refer a patient with secondary AML from community practice to an academic or specialized leukemia program should be based on a combination of disease complexity, treatment requirements, and the community center's capabilities, while emphasizing the importance of ongoing collaboration and education to enhance patient care across all settings.

Optimizing AML Care Through Academic-Community Collaboration

Panelists discuss how treating secondary AML in the community setting requires a multifaceted approach, emphasizing early diagnosis, risk stratification, timely referral when necessary, and close collaboration with academic centers to provide optimal patient care.

Implementing Updates to AML Classification Guidelines

EP: 1.Implementing Updates to AML Classification Guidelines

EP: 2.Treatment Goals in Secondary AML

EP: 3.The Role of Molecular and Cytogenetic Testing in Secondary AML

EP: 4.Patient-Centered Decision-Making in Secondary AML Treatment

EP: 5.Assessing Transplant Eligibility and Fitness for Intensive Chemotherapy

EP: 6.Evidence-Based Approaches to Intensive Chemotherapy in Secondary AML

EP: 7.Navigating Intensive Chemotherapy in the Community Setting

EP: 8.Optimizing AML Care Through Academic-Community Collaboration

EP: 9.Practice Pearls for Treatment of Secondary AML in the Community Setting

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