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Opinion|Videos|January 15, 2025

Insights from POLARIX: How do Novel Perspectives Influence Treatment Outcomes in DLBCL?

Author(s)David Miklos, MD, Haifaa Abdulhaq, MD, Frederick Locke, MD

An expert discussion on evolving first-line treatment strategies for newly diagnosed diffuse large B-cell lymphoma (DLBCL), incorporating insights from the 2024 NCCN guidelines, unmet needs in 1L therapies, and the impact of POLARIX trial updates on the use of Pola+R-CHP in clinical practice.

Episodes in this series

EP. 1 Emerging Updates in Front-line Treatment Approach of DLBCL

EP. 1 Emerging Updates in Front-line Treatment Approach of DLBCL

EP. 2 Insights from POLARIX: How do Novel Perspectives Influence Treatment Outcomes in DLBCL?

EP. 2 Insights from POLARIX: How do Novel Perspectives Influence Treatment Outcomes in DLBCL?

EP. 3 The Evolving First-line Treatment Approach for DLBCL

EP. 3 The Evolving First-line Treatment Approach for DLBCL

EP. 4 Future Considerations for Front-line Treatment of DLBCL

EP. 4 Future Considerations for Front-line Treatment of DLBCL

EP. 5 Role of Testing in Treatment Decisions - ClonoSeq, PhaseSeq, MRD+Disease

EP. 5 Role of Testing in Treatment Decisions - ClonoSeq, PhaseSeq, MRD+Disease

$EP. 6 Second-line Treatment Landscape in Relapsed/Refractory DLBCL$

EP. 6 Second-line Treatment Landscape in Relapsed/Refractory DLBCL

$EP. 7 The Emerging Role of Second-line CAR T-cell Therapy in Relapsed/Refractory DLBCL$

EP. 7 The Emerging Role of Second-line CAR T-cell Therapy in Relapsed/Refractory DLBCL

$EP. 8 Safety Considerations for Second-line CAR T-cell Therapy in Relapsed/Refractory DLBCL$

EP. 8 Safety Considerations for Second-line CAR T-cell Therapy in Relapsed/Refractory DLBCL

$EP. 9 Real World Perspectives: Outcomes for CAR T-cell Therapy in Relapsed/Refractory DLBCL$

EP. 9 Real World Perspectives: Outcomes for CAR T-cell Therapy in Relapsed/Refractory DLBCL

$EP. 10 Real World Perspectives: Considerations and Challenges for CAR T-cell Therapy in Relapsed/Refractory DLBCL$

EP. 10 Real World Perspectives: Considerations and Challenges for CAR T-cell Therapy in Relapsed/Refractory DLBCL

$EP. 11 Additional Perspectives Beyond CAR T-cell Regimens in Relapsed/Refractory DLBCL.: Bispecifics$

EP. 11 Additional Perspectives Beyond CAR T-cell Regimens in Relapsed/Refractory DLBCL.: Bispecifics

$EP. 12 Academic Insights for the Treatment of Later Relapsed/Refractory DLBCL$

EP. 12 Academic Insights for the Treatment of Later Relapsed/Refractory DLBCL

$EP. 13 Bispecific Antibodies in the Relapsed/Refractory DLBCL Treatment Landscape$

EP. 13 Bispecific Antibodies in the Relapsed/Refractory DLBCL Treatment Landscape

$EP. 14 Future Perspectives for the Treatment of Relapsed/Refractory DLBCL$

EP. 14 Future Perspectives for the Treatment of Relapsed/Refractory DLBCL

Video content above is prompted by the following:

Discuss treatment strategies for newly diagnosed DLBCL (NCCN guidelines). What factors are most important when selecting treatments for 1L DLBCL?
What are unmet needs in 1L treatment options in DLBCL.
With the 2024 NCCN update concerning Pola+R-CHP in DLBCL, how is your standard approach to 1L treatment of DLBCL evolving?
How does the prolonged follow-up from POLARIX change your view on how and when to use POLA+R-CHP Salles et al. ASH 2024?

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