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Commentary|Videos|October 29, 2024

Lorlatinib in ROS1+ Advanced NSCLC After Crizotinib and Chemotherapy

Author(s)Benjamin Besse, MD, Gregory J. Riely, MD, PhD

Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss data for lorlatinib in ROS1-positive NSCLC after crizotinib and chemotherapy.

Episodes in this series

Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss testing for ALK-positive and ROS1-positive non–small cell lung cancer.

EP. 1 Testing for ALK Fusions and ROS1 Rearrangements in NSCLC

Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss data for NVL-655 in ALK-positive NSCLC and other ALK-positive solid tumors.

EP. 2 Data for NVL-655 in Advanced ALK+ NSCLC and Solid Tumors from the ALKOVE-1 Trial

Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss data for zidesamtinib in ROS1-positive non–small cell lung cancer.

EP. 3 Findings for Zidesamtinib in Advanced ROS1+ NSCLC and Other Solid Tumors

Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss preclinical CNS data for the ROS1 inhibitor zidesamtinib.

EP. 4 Preclinical CNS Data for Zidesamtinib and Other ROS1 Inhibitors

Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, on progression patterns and subsequent therapies after lorlatinib in ALK-positive NSCLC.

EP. 5 Progression Patterns and Subsequent Therapies after Lorlatinib in ALK+ NSCLC

Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss data for taletrectinib in ROS1-positive advanced non–small cell lung cancer.

EP. 6 The TRUST-II Study of Taletrectinib in ROS1+ Advanced NSCLC

Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss data for lorlatinib in ROS1-positive NSCLC after crizotinib and chemotherapy.

EP. 7 Lorlatinib in ROS1+ Advanced NSCLC After Crizotinib and Chemotherapy

Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss unmet needs and future research directions in ALK-positive and ROS1-positive NSCLC.

EP. 8 Future Research Directions in ALK+ and ROS1+ NSCLC

Clinicians referring a patient to MSK can do so by visiting msk.org/refer, emailing referapatient@mskcc.org, or by calling 833-315-2722.

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