Managing Toxicities With TROP2-Directed ADCs in Advanced NSCLC: Best Practices and Management Strategies

Author(s):

Jonathan Riess, MD, MS, UC Davis Comprehensive Cancer Center,Christine Bestvina, MD, University of Chicago

This episode examines the management of ILD/pneumonitis associated with TROP2-directed ADCs in patients with advanced NSCLC and strategies for mitigating these risks, addresses hematologic toxicities related to docetaxel, and discusses the improved tolerability and lower incidence of severe treatment-emergent adverse events with Dato-DXd compared with docetaxel.

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EP: 7.Managing Toxicities With TROP2-Directed ADCs in Advanced NSCLC: Best Practices and Management Strategies

Video content above is prompted by the following:

Have you observed ILD/pneumonitis associated with a TROP2-directed ADC among your patients with progressive, later-stage, or metastatic NSCLC either in practice or in the context of a clinical trial?
In your opinion, what are the most effective mitigation or prevention strategies that you follow to avoid precluding use of such therapy?
What has been your experience with docetaxel-related hematologic toxicities among patients with advanced or metastatic NSCLC? How do you manage these toxicities?
Are there laboratory threshold values that motivate you to interrupt, reduce, or discontinue dosing?
How encouraged are you by the lower overall incidence of grade greater than or equal to 3 treatment-emergent adverse events and improved tolerability with Dato-DXd vs docetaxel (25% vs 41%)? What is your experience with toxicity management of Dato-DXd?