Navigating FGFRi Therapy Adverse Effects: Nail Toxicities

EP: 1.Intrahepatic Cholangiocarcinoma Overview

EP: 2.Risk Factors Leading to Various Liver Cancers

EP: 3.Clinical Presentations of Patients With Cholangiocarcinoma

EP: 4.The Role of Biomarker Testing in Diagnosing Cholangiocarcinoma

EP: 5.First- and Second-Line Treatment Options for Intrahepatic Cholangiocarcinoma With FGFR2 Fusions or Alterations

EP: 6.Next-Gen Inhibitors Shaping Cholangiocarcinoma Treatment Landscape

EP: 7.Key Highlights For Patient Education Surrounding FGFR Inhibitors

EP: 8.Common Adverse Events Associated With FGFRi Therapy

EP: 9.Patient Perspective Regarding FGFRi Adverse Event Profiles

EP: 10.Symptoms Associated With Eye-Related Toxicities Amid FGFRi Therapy

EP: 11.Monitoring and Managing Hyperphosphatemia

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EP: 12.Navigating FGFRi Therapy Adverse Effects: Nail Toxicities

EP: 13.FGFRi-Related Stomatitis and Dry Mouth Impacting Patient Quality of Life

EP: 14.Key Takeaways For Treating Patients Diagnosed With Cholangiocarcinoma

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This is a video synopsis/summary of an OncLive Insights involving Lipika Goyal, MD; Chaundra Bishop; R. Katie Kelley, MD; and Caroline Kuhlman, NP.

Nail toxicity is a nearly universal adverse effect of FGFR inhibitors such as pemigatinib and futibatinib. Changes range from mild thickening and ridging to severe onycholysis (nail detachment) or complete nail loss, usually starting after 3 to 6 months on treatment. The fragmented, thickened nails can become painful, foul smelling, and embarrassing. Cracking around the nailbeds also risks bacterial or fungal infections such as paronychia. Patients should be warned to expect nail changes. To help mitigate issues, nails should be kept clean with vinegar soaks and antimicrobial ointments/solutions. Oral or topical antibiotics can treat infections. Dead nail material can be removed to prevent catching and discomfort. By 6 to 8 months after nail toxicity begins, most patients have complete nail loss, leaving only the matrix, which is often better tolerated than the fragmentation phase.

Video synopsis is AI-generated and reviewed by OncLive® editorial staff.