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The neoadjuvant/adjuvant pembrolizumab and chemotherapy combination was approved by the FDA in October 2023 for use in this patient population.

Perioperative Pembrolizumab Regimen Upholds Survival Benefit in Resectable NSCLC

Zongertinib demonstrated durable efficacy in patients with pretreated advanced HER2-mutant non–small cell lung cancer.

Zongertinib Elicits Durable Responses in Pretreated Advanced HER2-Mutant NSCLC 

Second-line lenvatinib had clinically meaningful efficacy in patients with advanced HCC after progression on atezolizumab plus bevacizumab.

Lenvatinib Shows Efficacy in Advanced HCC Post-Progression on Atezolizumab/Bevacizumab

The phase 3 TROPiCS-04 study missed its primary end point of improved OS with sacituzumab govitecan vs chemotherapy in patients with urothelial cancer.

Sacituzumab Govitecan Does Not Significantly Improve OS in Pretreated Urothelial Carcinoma

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Articles

The FDA awards accelerated approval to encorafenib regimen in BRAF V600E+ CRC, ensartinib wins approval in ALK+ non–small cell lung cancer, and more.

The OncFive: Top Oncology Articles for the Week of 12/15


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Adding dostarlimab to chemotherapy and niraparib maintenance improved progression-free survival in first-line advanced ovarian cancer.

Addition of Dostarlimab to Chemo and Niraparib Maintenance Boosts PFS in Advanced Ovarian Cancer

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The addition of pegcrisantaspase to venetoclax may overcome resistance to prior BCL-2 inhibitor–based regimens for patients with relapsed/refractory AML. 

Venetoclax Plus PegC May Overcome Resistance to Prior BCL-2 Inhibitors in R/R AML 

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The Evolving Treatment Landscape in Light Chain Amyloidosis with Cardiac Involvement

Ongoing AFFIRM-AL Trial Background, Patient Eligibility, and Active Enrollment

Videos

Expert oncologists discuss the current treatment landscape and latest data in the treatment of patients with AL amyloidosis with cardiac involvement.

Expert oncologists Dr. Jeffrey Zonder and Dr. Shaji Kumar discuss AL amyloidosis background, typical patient profiles, and disease staging and risk stratification.

AL Amyloidosis: Background, Patient Profile, and Staging

Dr. Kumar discusses best practices for accurately and prompt diagnosing AL amyloidosis as well as navigating differential diagnosis.

Navigating the Differential Diagnosis of AL Amyloidosis

Dr. Zonder discusses the current treatment landscape in AL amyloidosis, highlighting recent advances.

Treatment Approaches in AL Amyloidosis 

Expert oncologist Dr. Kumar provides his assessment of unmet needs in AL Amyloidosis, particularly patients with cardiac involvement.

Limitations of Available Treatment Options for Patients with Cardiac Involvement 

Drs. Kumar and Zonder discuss results from the Phase III Vital trial investigating birtamimab and key takeaways.

Birtamimab in AL Amyloidosis: Key Takeaways from the Phase III VITAL Trial

Dr. Zonder discusses the safety profile of birtamimab in the VITAL study and the clinical implications.

Birtamimab Safety Profile in the VITAL Study

Dr. Kumar discusses strategies for managing adverse events in patients with AL amyloidosis.

Adverse Event Management in AL Amyloidosis

Dr. Kumar and Dr. Zonder discuss the ongoing confirmatory Phase III AFFIRM-AL trial investigating the efficacy and safety of birtamimab and ongoing recruitment in the trial.

Expert oncologists discuss the progression treatment landscape in AL amyloidosis and agents of investigation.

Revolutionizing the AL Amyloidosis Treatment Paradigm: Novel Agents and Combination Approaches

Dr. Zonder and Dr. Kumar share their clinical pearls and perspectives on future directions in the treatment of AL amyloidosis.

Ongoing AFFIRM-AL Trial Background, Patient Eligibility, and Active Enrollment

EP: 1.AL Amyloidosis: Background, Patient Profile, and Staging

EP: 2.Navigating the Differential Diagnosis of AL Amyloidosis

EP: 3.Treatment Approaches in AL Amyloidosis

EP: 4.Limitations of Available Treatment Options for Patients with Cardiac Involvement

EP: 5.Birtamimab in AL Amyloidosis: Key Takeaways from the Phase III VITAL Trial

EP: 6.Birtamimab Safety Profile in the VITAL Study

EP: 7.Adverse Event Management in AL Amyloidosis

EP: 8.Ongoing AFFIRM-AL Trial Background, Patient Eligibility, and Active Enrollment

EP: 9.Revolutionizing the AL Amyloidosis Treatment Paradigm: Novel Agents and Combination Approaches

EP: 10.Clinical Pearls and Future Directions in AL Amyloidosis

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