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Opinion|Videos|October 22, 2024

Second-Line LR- MDS Setting: Treatment Options and Considerations

Author(s)James K. McCloskey, MD, John Theurer Cancer Center, Thomas W. LeBlanc, MD, MA

Panelists discuss how they determine thresholds for changing therapy in patients with MDS, evaluate second-line treatment options including the potential use of ESAs after luspatercept, and offer key takeaways for community colleagues managing similar clinical scenarios.

Episodes in this series

2 KOLs are featured in this series.

EP. 1 Understanding Myelodysplastic Syndromes (MDS): Diagnosis, Classification, and Risk Assessment

2 KOLs are featured in this series.

EP. 2 Navigating the Heterogeneity of LR-MDS: Importance of Molecular Testing & Risk Stratifying

2 KOLs are featured in this series.

EP. 3 Clinical Scenario 1: 76-Year-Old Man With Newly Diagnosed MDS With Symptomatic Anemia, RS Positive

2 KOLs are featured in this series.

EP. 4 Tailoring Treatment for LR-MDS: Patient Factors, Treatment Goals, and Patient Outcomes

2 KOLs are featured in this series.

EP. 5 First-Line Luspatercept in LR-MDS: A Deep Dive Into the COMMANDS Trial and Clinical Implications in the Real-Life Practice Setting

2 KOLs are featured in this series.

EP. 6 Managing Luspatercept Therapy: Dosing, Adverse Effects, and Monitoring

2 KOLs are featured in this series.

EP. 7 Second-Line LR- MDS Setting: Treatment Options and Considerations

2 KOLs are featured in this series.

EP. 8 Patient Profile: 66-Year-Old Woman with Newly Diagnosed LR-MDS, RS Negative

2 KOLs are featured in this series.

EP. 9 Luspatercept Role in the RS-Negative Population and Expert Perspectives on the Role of EPO Levels

2 KOLs are featured in this series.

EP. 10 First-Line ESA vs Luspatercept in LR-MDS: Choosing the Most Appropriate Treatment Option for Each Individual Patient

2 KOLs are featured in this series.

EP. 11 Imetelstat and IMerge Trial Review

2 KOLs are featured in this series.

EP. 12 Looking Ahead in LR-MDS: Future Agents and/or Combination Strategies

2 KOLs are featured in this series.

EP. 13 The Future of Lower-Risk MDS: Closing Thoughts and Unmet Needs

Video content above is prompted by the following:

What is your threshold for changing therapy in your clinical practice?
What treatment options would you consider in the second-line setting for this patient? Do you consider trialing ESAs post luspatercept?
What are some key takeaways you can offer community colleagues from this clinical scenario and discussion?

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