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Opinion|Videos|June 10, 2024

TKI Regimens and Other Novel Approaches in Later Line Treatment of HER2+ mBC Setting

Author(s)Tiffany A. Traina, MD, VK Gadi, MD, PhD, Heather McArthur, MD, MPH

Vijayakrishna Gadi, MD, PhD, shares his insights on managing patients with HER2-positive metastatic breast cancer who have progressed on second and third-line treatments, stressing the potential benefits of incorporating small molecules, tyrosine kinase inhibitors (TKIs), chemotherapy, and enrolling patients in clinical trials to optimize outcomes.

Episodes in this series

A panel of 3 experts on breast cancer

EP. 1 The Role of HER2 in Breast Cancer and Treatment Goals for HER+ Metastatic Breast Cancer Patients

A panel of 3 experts on breast cancer

EP. 2 Evolution of the HER2+ Metastatic Breast Cancer Treatment Landscape

A panel of 3 experts on breast cancer

EP. 3 First-Line HER2+ Metastatic Breast Cancer Trials in Focus

A panel of 3 experts on breast cancer

EP. 4 Case Study: Treatment Sequencing for a 62 Year Old Woman with HER2+ Metastatic Breast Cancer After Progression on T-DXd

A panel of 3 experts on breast cancer

EP. 5 Evidence-Based Sequencing for HER2+ mBC After Progression: Clinical Trial Data and NCCN Guideline Updates

A panel of 3 experts on breast cancer

EP. 6 Managing Adverse Events and Toxicities HER2+ Metastatic Breast Cancer

A panel of 3 experts on breast cancer

EP. 7 TKI Regimens and Other Novel Approaches in Later Line Treatment of HER2+ mBC Setting

A panel of 3 experts on breast cancer

EP. 8 Case Study of a 54-Year-Old Woman With HER2+ Metastatic Breast Cancer and Brain Metastases: Optimal Treatment Approaches

A panel of 3 experts on breast cancer

EP. 9 Exploring the Latest Updates from the HER2CLIMB Trial Evaluating Tucatinib in Patients with Brain Metasteses

A panel of 3 experts on breast cancer

EP. 10 Managing Brain Metastases in HER2+ Metastatic Breast Cancer: Clinical Trial Data and Multidisciplinary Approaches

A panel of 3 experts on breast cancer

EP. 11 Evolving Treatment Paradigm in HER+ Breast Cancer: Future Directions

Video content above is prompted by the following questions:

For patients who progress through multiple HER2-targeted therapies, when would you consider chemotherapy and what specific regimens?
Are there data supporting the use of continuing HER2 blockade with chemotherapy in later lines?

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