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Opinion|Videos|January 30, 2025

Translating Data With Oral SERDs to Practice: EMBER-3, SERENA-2, and Ongoing Trials

Author(s)Katherine Clifton, MD, Shipra Gandhi, MD

Dr. Gandhi and Dr. Clifton discuss incorporating imlunestrant plus abemaciclib into treatment sequencing for hormone receptor–positive/HER2-negative (HR+/HER2–) metastatic breast cancer (BC), considering factors such as ESR1 mutation status, prior CDK4/6 inhibitor (CDK4/6i) use, and visceral metastases, while also highlighting key trials of selective estrogen receptor degraders (SERDs), including SERENA-2 and OPERA-01.

Episodes in this series

EP. 1 Shifting Paradigms: Biomarker Testing and ESR1 Mutation Surveillance in HR+ HER2- Breast Cancer

EP. 1 Shifting Paradigms: Biomarker Testing and ESR1 Mutation Surveillance in HR+ HER2- Breast Cancer

EP. 2 Endocrine Sensitivity and the Prognostic and Clinical Implications

EP. 2 Endocrine Sensitivity and the Prognostic and Clinical Implications

EP. 3 Approved and Investigational SERDs in HR+/HER2– Breast Cancer

EP. 3 Approved and Investigational SERDs in HR+/HER2– Breast Cancer

EP. 4 Imlunestrant Clinical Data: Insights From the EMBER and EMBER-3 Trials

EP. 4 Imlunestrant Clinical Data: Insights From the EMBER and EMBER-3 Trials

EP. 5 Translating Data With Oral SERDs to Practice: EMBER-3, SERENA-2, and Ongoing Trials

EP. 5 Translating Data With Oral SERDs to Practice: EMBER-3, SERENA-2, and Ongoing Trials

EP. 6 Insights From SABCS 2024 and Future Directions in Breast Cancer

EP. 6 Insights From SABCS 2024 and Future Directions in Breast Cancer

Video content above is prompted by the following:

Based on the data seen in the EMBER-3 trial, how do you anticipate incorporating imlunestrant plus abemaciclib into your treatment sequencing for patients with HR+/HER2– metastatic BC? In which patients and in which line of therapy would you consider using this combination?
- Based on subgroup data, how might you consider these factors in your clinical decision-making?
  - ESR1 mutation vs wild type
  - Prior CDK4/6i
  - Duration of prior CDK4/6i
  - Presence of visceral metastases
Please highlight other trials of note investigating SERDs in HR+/HER2– BC:
- SERENA-2: camizestrant vs fulvestrant
- OPERA-01: palazestrant vs standard-of-care endocrine therapy
- Any others (eg, EMBER-4, SERENA-4,ELEVATE, etc)

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