Transplant Complications and Survival Outcomes

EP: 1.Role of Allogeneic Transplants in Hematologic Malignancies

EP: 2.Hematologic Malignancies and Transplant Options and Conditioning Regimens Used in Allo-HSCT

EP: 3.Supportive Care Measures for Patients Planning to Receive an Allogenic Transplant

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EP: 4.Transplant Complications and Survival Outcomes

EP: 5.Clinical Trial Update: CTN Trial

EP: 6.Graft-versus-Host Disease Prophylaxis and Management

EP: 7.Patient Case Studies of GvHD

EP: 8.Emerging Cellular Therapies in Hematologic Malignancies

EP: 9.Transplant in the Elderly Population

EP: 10.Toxicity Assessment of Precision-Engineered Allo-HSCT

EP: 11.The Role of Allo-HSCT in Higher-Risk MDS

EP: 12.Investigational Allo-HSCT for Advanced Hematologic Malignancies

EP: 13.The Future of Allo-HSCT and Cellular Therapies

EP: 14.OncLive Peer Exchange on Allo-HSCT: Conclusion of Discussion

This is a video synopsis/summary of a Peer Exchange featuring Miguel-Angel Perales, MD; Nelli Bejanyan, MD; Amandeep Salhotra, MD; and Arpita Gandhi, MD, MS.

The panel discusses the importance of considering outcomes beyond traditional measures such as overall survival and relapse-free survival when evaluating the success of allogeneic hematopoietic stem cell transplantation (allo-HSCT). While these metrics have been the primary focus in the past, patients are often more concerned with their ability to return to their normal lives after transplantation.

Newer composite end points, such as graft-vs-host disease–free, relapse-free survival, provide a more comprehensive assessment of transplantation outcomes by incorporating acute and chronic graft-vs-host disease in addition to relapse-free survival. This composite end point has become a new standard for measuring outcomes in clinical trials.

The panel emphasizes the importance of using these composite end points, particularly in ongoing clinical trials, to better capture the patient experience and provide a more accurate representation of the overall success of transplantation.

Video synopsis is AI-generated and reviewed by OncLive® editorial staff.