Treatment Considerations and Sequencing in Multiple Myeloma

EP: 1.The Evolving Landscape of Newly Diagnosed Multiple Myeloma

EP: 2.Highlights from ASH 2023 in Transplant-Eligible NDMM

EP: 3.Advances in the Treatment of High-Risk MM

EP: 4.Role of Transplant and MRD in Newly Diagnosed MM

EP: 5.The Evolving Treatment Paradigm for Transplant Ineligible MM

EP: 6.Treatment of Multiple Myeloma at Early Relapse

EP: 7.Potential Role for CAR T-Cell Therapy in MM at Early Relapse

EP: 8.Updates on BCMA-Targeting Bispecifics in MM

EP: 9.Real-World Evidence and Selecting Optimal Bispecifics in Multiple Myeloma

EP: 10.Step-Up Dosing Practices for Bispecifics in Multiple Myeloma

EP: 11.Adverse Effects Related to Bispecifics in Multiple Myeloma

EP: 12.GPRC5D-Targeting Bispecifics in Multiple Myeloma

EP: 13.CAR T-Cell Therapy in Multiple Myeloma: Role in the Treatment Landscape

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EP: 14.Treatment Considerations and Sequencing in Multiple Myeloma

This is a video synopsis/summary of a Peer Exchange featuring Krina K. Patel, MD, MSc; Amrita Krishnan, MD; Caitlin Costello, MD; Saad Z. Usmani, MD, MBA, FACP; and Rafat Abonour, MD.

The discussion focuses on sequencing B-cell maturation antigen (BCMA)–targeted therapies. Continuing one BCMA bispecific antibody after progression on another may have limited efficacy due to outgrowth of BCMA loss mutations and T-cell exhaustion. A period of non-BCMA–directed therapy could help restore T-cell fitness before switching targets, like to GPRC5D with cibisatamab or teclistamab. More clinical and biologic tools are still needed to better understand resistance mechanisms among bispecific antibodies, antibody-drug conjugates, and CAR T-cell therapy to inform sequencing.

Off-the-shelf allogeneic CAR T-cell therapy could facilitate faster retreatment compared to autologous manufacturing. Continued research into optimal sequencing strategies is still needed and will be better informed by longer follow-up of currently available BCMA therapies.

Video synopsis is AI-generated and reviewed by OncLive® editorial staff.