What is on the Horizon for Adjuvant Therapy in Early-Stage Breast Cancer?

EP: 1.Clinical Case 1: High-Risk Early-Stage HR+ Breast Cancer

EP: 2.Risk Factors and the Treatment Plan

EP: 3.Endocrine Therapy for Early-Stage Breast Cancer

EP: 4.Key Findings from the monarchE Trial

EP: 5.Individualizing Care with CDK 4/6 Inhibitors

EP: 6.Age-Dependent Results With CDK 4/6 Inhibitors

EP: 7.Dosing CDK 4/6 Inhibitors

EP: 8.Implementing Trial Data to Our Practice

EP: 9.Selecting Endocrine Therapy in BRCA1/BRCA2+ Breast Cancer

EP: 10.Clinical Case 2: High-Risk Early-Stage HR+ Breast Cancer

EP: 11.Risk of Recurrence

EP: 12.Key Findings from the NATALEE Trial

EP: 13.Impact of Trial Data on Clinical Practice

EP: 14.Managing Toxicities and Adverse Events of CDK 4/6 Inhibitors

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EP: 15.What is on the Horizon for Adjuvant Therapy in Early-Stage Breast Cancer?

Transcript:

Rachel Layman, MD: This has been a great conversation. I was curious, what up-and-coming things are you looking forward to in the adjuvant setting?

Stephanie Graff, MD, FACP: In the adjuvant setting, I am excited about some of the trials that are going on that are going to be looking at questions around triple-negative breast cancer. I guess I can say that I kind of hate KEYNOTE 522 [NCT03036488]; it’s a lot of chemotherapy. It’s a very hard treatment to put patients through, and we have trials like OptimICE-PCR [NCT05812807], looking at eliminating the year of adjuvant therapy for patients who have a pathologic complete response. Trials are looking at antibody-drug conjugates, in a KATHERINE-like [NCT01772472] approach for patients who don’t have a pathologic complete response, because honestly, patients who do not have a pathologic complete response after that much treatment worry me a lot. Then importantly, there are some antibody-drug conjugate trials going on in the neoadjuvant space looking to eliminate some of those chemotherapeutics in that 4-drug chemotherapy backbone of KEYNOTE 522, which I think would be a meaningful way to minimize toxicity and streamline that complicated, hard neoadjuvant therapy for patients. I think that’s the next thing on the horizon for early-stage breast cancer that I’m looking forward to. What about you?

Rachel Layman, MD: I agree, and along the theme, I think we’re going to be able to de-escalate therapy for patients who don’t need it and escalate therapy for patients who do. Signatera circulating tumor DNA [ctDNA] testing has been approved by Medicare, although we’re not doing that as the standard of care at our institution yet. I think that although it increases the risk of a recurrence by having a positive test, we don’t really know what to do with that. I am looking forward to some trials that may incorporate the [ctDNA] in which perhaps if someone has a positive test, then you might want to switch therapy or escalate therapy, and if someone has a negative test, maybe you can de-escalate therapy in some of these patients. I think it’s a really exciting time, and I think we’ll be able to optimize therapy a little bit better to give just the right amount to patients.

Stephanie Graff, MD, FACP: I’m hopeful that we get to a place where we can use the tools at our disposal smarter for the best care of the patients who we’re lucky to have in our clinics.

Rachel Layman, MD: Very good. Do you have any closing thoughts?

Stephanie Graff, MD, FACP: No. I’m thankful for everybody who joined us today, and I’m glad that I got to do this with you. Thanks, everyone, for being here with Dr Layman and me for this OncLive® My Treatment Approachprogram, and I hope you found this program useful and valuable for the management of your patients with hormone receptor-positive early breast cancer. Dr Layman and I really enjoyed this discussion, and we will see you next time. Thanks.

Rachel Layman, MD: Thank you.

Transcript edited for clarity.