Assessment and Grading of Acute GVHD

EP: 1.Clinical Scenario: A 38-Year-Old Man with Ph+ ALL

EP: 2.GVHD Incidence and Pathophysiology

EP: 3.Conditioning Regimens for Stem Cell Transplantation

EP: 4.Risk Factors for Acute and Chronic GVHD

EP: 5.The GVHD Prophylaxis Landscape

EP: 6.Acute GVHD Presentation and Diagnosis

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EP: 7.Assessment and Grading of Acute GVHD

EP: 8.Frontline Steroid Treatment for Acute GVHD

EP: 9.Education and Resources for Patients with GVHD

EP: 10.Clinical Scenario: Chronic Graft Versus Host Disease

EP: 11.Chronic GVHD Incidence and Risk Factors

EP: 12.Challenges with Early Diagnosis of GVHD

EP: 13.Frontline Treatment of Chronic GVHD

EP: 14.Steroid Administration for Chronic GVHD

EP: 15.The Steroid-Refractory Chronic GVHD Landscape

EP: 16.Selecting Therapy for Steroid-Refractory Chronic GVHD

EP: 17.Monitoring and Follow-Up of Patients with Chronic GVHD

Transcript:

Bonnie J. Dirr, APRN: In terms of grading acute graft-vs-host disease [GVHD], can you please talk to us about assessment in the grading scales? And what scales do you use most often?

Mahasweta Gooptu, MD: I alluded to it a little bit with the last question. For acute GVHD, we use the Glucksberg grading system, which is pretty standard and is used by most centers, by which we see, first, then skin. We look at the body surface area involvement. For diarrhea, we look at the volume of diarrhea, and for the liver we look at the degree of hyperbilirubinemia and, for example, for skin, less than 25% is stage 1, 25% to 50% to stage 2. If you have erythroderma, it’s stage 3, and if in addition you have… then that is stage 4. Then similarly you stage each organ and then you put together the numbers for the staging and give the patient a grade. For that we follow the Glucksberg scale. We follow a different method of grading for chronic GVHD, which I think we’ll come to later in the presentation.

Transcript is AI-generated and edited for clarity and readability.