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Opinion|Videos|January 1, 2025

Considerations for First-Line Targeted Therapies in Metastatic RET-Positive NSCLC

Author(s)Heather A. Wakelee, MD, FASCO, Jacob Sands, MD

Panelists discuss the specific factors that influence the decision to initiate one of the NCCN guideline–preferred RET inhibitors, selpercatinib or pralsetinib, over the other in the treatment of RET fusion–positive NSCLC.

Episodes in this series

EP. 1 Patient Case: 67 Year-Old Male With Stage IIIB+ NSCLC Awaiting for Mutation Testing

EP. 1 Patient Case: 67 Year-Old Male With Stage IIIB+ NSCLC Awaiting for Mutation Testing

EP. 2 Next Steps to Stage IIIB NSCLC Patient Case Awaiting Molecular Testing and Usability of Liquid Biopsy

EP. 2 Next Steps to Stage IIIB NSCLC Patient Case Awaiting Molecular Testing and Usability of Liquid Biopsy

EP. 3 Testing Methodologies and Standards in Metastatic NSCLC

EP. 3 Testing Methodologies and Standards in Metastatic NSCLC

EP. 4 Practical Considerations in Metastatic NSCLC: Access and Timing of Testing

EP. 4 Practical Considerations in Metastatic NSCLC: Access and Timing of Testing

EP. 5 Clinical-Decision Making: When to Treat Advanced NSCLC Without Mutational Results

EP. 5 Clinical-Decision Making: When to Treat Advanced NSCLC Without Mutational Results

EP. 6 Initial Approach to Management of RET-Positive NSCLC

EP. 6 Initial Approach to Management of RET-Positive NSCLC

EP. 7 Patient and Therapy Considerations Guiding Initiation of Treatment in RET-Positive NSCLC

EP. 7 Patient and Therapy Considerations Guiding Initiation of Treatment in RET-Positive NSCLC

EP. 8 Considerations for First-Line Targeted Therapies in Metastatic RET-Positive NSCLC

EP. 8 Considerations for First-Line Targeted Therapies in Metastatic RET-Positive NSCLC

EP. 9 Role of Immunotherapy and Chemotherapy in RET-Positive NSCLC

EP. 9 Role of Immunotherapy and Chemotherapy in RET-Positive NSCLC

EP. 10 Managing RET Inhibitor Treatment-Related Adverse Events

EP. 10 Managing RET Inhibitor Treatment-Related Adverse Events

EP. 11 Monitoring Patients With RET-Positive NSCLC

EP. 11 Monitoring Patients With RET-Positive NSCLC

EP. 12 Unmet Needs and Future Perspectives of RET-Positive NSCLC

EP. 12 Unmet Needs and Future Perspectives of RET-Positive NSCLC

Dr Wakelee to Dr Sands: What specific factors aid in your decision to initiate one of the NCCN guideline–preferred RET inhibitors (selpercatinib and pralsetinib) over the other?

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