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Opinion|Videos|June 25, 2024

Dr Wulff-Burchfield Reviews CheckMate 214 and CheckMate 9ER

Author(s)Pedro Barata, MD, MSc, Martin H. Voss, MD, Elizabeth Wulff-Burchfield, MD

The panelists examine the latest findings from the CheckMate 214 trial, which assessed the combination of nivolumab and ipilimumab (nivo + ipi) as a first-line treatment for advanced renal cell carcinoma, focusing on efficacy, safety, and quality of life outcomes.

Episodes in this series

4 KOLs are featured in this series

EP. 1 Treatment Selection in the Frontline Setting of Advanced Clear Cell RCC

4 KOLs are featured in this series

EP. 2 Dr Wulff-Burchfield Reviews CheckMate 214 and CheckMate 9ER

4 KOLs are featured in this series

EP. 3 Dr Xu Reviews Data from the CLEAR Trial and Recent Analyses at ASCO 2024 - Lenvatinib + Pembrolizumab in Frontline Advanced RCC

4 KOLs are featured in this series

EP. 4 Dr Voss Shares Highlights from the COSMIC-313 and LITESPARK-024 Trials

4 KOLs are featured in this series

EP. 5 Exciting Data and Trials in Progress from ASCO 2024

4 KOLs are featured in this series

EP. 6 Ongoing RCC Clinical Trials that may Impact Practice

4 KOLs are featured in this series

EP. 7 Dr Xu Provides Clinical Perspective on the CONTACT-03 Trial Outcomes

4 KOLs are featured in this series

EP. 8 Dr Voss Application of Updated KEYNOTE-564 Data

4 KOLs are featured in this series

EP. 9 Guiding Sequencing & Finding a Contemporary Regimen/ Approach to Treatment Post-Checkpoint Inhibition

4 KOLs are featured in this series

EP. 10 World Health Organization (WHO) Classification Updates for Papillary RCC

4 KOLs are featured in this series

EP. 11 Additional Forward-Looking Data and Studies Beyond Frontline Therapy in RCC

4 KOLs are featured in this series

EP. 12 The Role of Chemotherapy in nccRCC Treatment

4 KOLs are featured in this series

EP. 13 Select Ongoing Trials for nccRCC and Impact on the Treatment Landscape

4 KOLs are featured in this series

EP. 14 Final Thoughts/Looking Forward

Please briefly discuss the recent data from the CheckMate 214 trial evaluating nivo + ipi for 1L treatment of advanced RCC.
1. 8-year follow-up and subgroup analyses – please comment on OS, DOR, PFS, TFS, and safety (Tannir et al., ASCO GU 2024 Abstract 363)
2. What insights do the recent HRQoL data provide? (Cella et al., Oncologist Jan 2024)
Please comment on the role of doublet regimens in the 1L setting for advanced RCC and their recent data updates.
1. CheckMate 9ER nivo + cabo
2. 55-month follow up (Bourlon et al., ASCO GU 2024 Abstract 362)
3. HRQoL (Bedke et al., ASCO GU 2024 Abstract 384)
4. Partitioned 4-year OS (Mantia et al., ASCO 2024 Abstract 4507)

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