Video

ESMO 2021 Updates in HER2+ Metastatic Gastric and Gastroesophageal Cancer

Author(s):

Sam Klempner, MD, Massachusetts General Hospital ,Daniel H. Ahn, DO, Mayo Clinic

Key opinion leaders in gastric cancers comment on ESMO 2021 updates in metastatic HER2+ esophagogastric adenocarcinoma and metastatic HER2+ gastric or gastroesophageal junction cancer.

Data from the following clinical trials are discussed:

  • LBA54 - Ipilimumab or FOLFOX in combination with nivolumab and trastuzumab in previously untreated HER2-positive locally advanced or metastatic esophagogastric adenocarcinoma (EGA): Results of the randomized phase 2 INTEGA trial (INTEGA)
  • LBA55 - Primary analysis of a phase 2 single-arm trial of trastuzumab deruxtecan (T-DXd) in western patients (Pts) with HER2-positive (HER2+) unresectable or metastatic gastric or gastroesophageal junction (GEJ) cancer who progressed on or after a trastuzumab-containing regimen (DESTINY-Gastric02)
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