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Opinion|Videos|November 11, 2024

Innovative Combination Strategies for Endometrial Cancer: Updates from LEAP and KEYNOTE-B21 Trials

Author(s)Angeles Alvarez Secord, MD, MHSc , Dana M. Chase, MD, FACOG, Bhavana Pothuri, MD

Panelists discuss emerging data from ongoing trials evaluating innovative combination strategies for endometrial cancer, including insights from the LEAP trial (pembrolizumab + lenvatinib) and the KEYNOTE-B21 trial (pembrolizumab + chemotherapy with or without radiotherapy). They also address treatment considerations for patients with sentinel lymph node–positive disease.

Episodes in this series

5 KOLs are featured in this series.

EP. 1 Approaching Biomarker Testing and Frontline Maintenance Therapy for Advanced Ovarian Cancer

5 KOLs are featured in this series.

EP. 2 Key Findings from the PRIMA Trial: Niraparib in 1L Maintenance for Advanced Ovarian Cancer

5 KOLs are featured in this series.

EP. 3 Duration of PARP Inhibitor Maintenance Therapy for Ovarian Cancer

5 KOLs are featured in this series.

EP. 4 Emerging Combinations in Maintenance Therapy for Ovarian Cancer

5 KOLs are featured in this series.

EP. 5 Optimizing Ovarian Cancer Care: PARP Resistance, Management of Oligoprogression, and Adverse Event Mitigation

5 KOLs are featured in this series.

EP. 6 Use of Trastuzumab Deruxtecan in Ovarian Cancer

5 KOLs are featured in this series.

EP. 7 Antibody-Drug Conjugates in Ovarian Cancer: Emerging Data and Treatment Integration

5 KOLs are featured in this series.

EP. 8 Navigating Treatment Strategies for Advanced Cervical Cancer: Localized Therapy, KEYNOTE-A18 Trial Data, and Frontline Approaches

5 KOLs are featured in this series.

EP. 9 Integrating Tisotumab Vedotin into Ovarian Cancer Therapy

5 KOLs are featured in this series.

EP. 10 Biomarker Testing in Advanced Endometrial Cancer: Approach, Key Markers, and Impact on Treatment Decisions

5 KOLs are featured in this series.

EP. 11 Managing Recurrent Endometrial Cancer: Treatment Strategies and RUBY Trial Insights

5 KOLs are featured in this series.

EP. 12 Durvalumab in Endometrial Cancer: DUO-E Trial Updates

5 KOLs are featured in this series.

EP. 13 Innovative Combination Strategies for Endometrial Cancer: Updates from LEAP and KEYNOTE-B21 Trials

5 KOLs are featured in this series.

EP. 14 T-DXd in Advanced Endometrial Cancer

5 KOLs are featured in this series.

EP. 15 Emerging ADCs in Advanced Endometrial Cancer: Anti-TROP2 and Anti-FR Agents

Video content above is prompted by the following:

Briefly comment on other emerging data from ongoing trials evaluating other combination strategies in this setting.

LEAP (pembrolizumab + lenvatinib)
KEYNOTE-B21 (pembrolizumab + CT±RT)
Spoke on sentinel lymph node–positive treatment

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