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Opinion|Videos|January 6, 2025

Insights Into Ongoing Investigational Studies in Lung LCNEC

Author(s)Martin Dietrich, MD, PhD, Soo-Ryum Yang, MD

Panelists discuss ongoing lung large cell neuroendocrine carcinoma (LCNEC) trials involving both familiar and novel agents, including phase 2 durvalumab + EP (1L), phase 2 LCNEC-ALPINE atezolizumab + EP (1L), phase 1/2 SKYBRIDGE PT217 DLL3/CD47 bispecific antibody (2L+), and phase 1 LB2102 DLL2-directed CAR T (2L+).

Episodes in this series

EP. 1 Lung Large Cell Neuroendocrine Carcinoma: A Rare but Aggressive Disease Intro

EP. 1 Lung Large Cell Neuroendocrine Carcinoma: A Rare but Aggressive Disease Intro

EP. 2 An Overview of the Molecular Characterization of Lung LCNEC

EP. 2 An Overview of the Molecular Characterization of Lung LCNEC

EP. 3 The Pathological Diagnosis of Lung LCNEC

EP. 3 The Pathological Diagnosis of Lung LCNEC

EP. 4 Biomarker Testing Strategies for Lung LCNEC

EP. 4 Biomarker Testing Strategies for Lung LCNEC

EP. 5 Biopsy Best Practices: Diagnosing Lung LCNEC

EP. 5 Biopsy Best Practices: Diagnosing Lung LCNEC

EP. 6 Lung LCNEC Diagnostic Challenges

EP. 6 Lung LCNEC Diagnostic Challenges

EP. 7 A Multidisciplinary Approach to Managing Lung LCNEC

EP. 7 A Multidisciplinary Approach to Managing Lung LCNEC

EP. 8 Lung LCNEC Disease Histology and Prognosis

EP. 8 Lung LCNEC Disease Histology and Prognosis

EP. 9 The Role of DLL3 in LCNEC of the Lung

EP. 9 The Role of DLL3 in LCNEC of the Lung

EP. 10 Insights on the LANCE Pilot Study on Lung LCNEC

EP. 10 Insights on the LANCE Pilot Study on Lung LCNEC

EP. 11 Novel Targeted Therapies for LCNEC of the Lung

EP. 11 Novel Targeted Therapies for LCNEC of the Lung

EP. 12 Overview of Studies of BI 764532 for Lung LCNEC

EP. 12 Overview of Studies of BI 764532 for Lung LCNEC

EP. 13 Insights Into Ongoing Investigational Studies in Lung LCNEC

EP. 13 Insights Into Ongoing Investigational Studies in Lung LCNEC

EP. 14 Potential Next-Generation Therapies for Lung LCNEC

EP. 14 Potential Next-Generation Therapies for Lung LCNEC

EP. 15 Unmet Needs in LCNEC

EP. 15 Unmet Needs in LCNEC

Please briefly describe and provide any thoughts for ongoing lung LCNEC trials, with both familiar and novel agents:
- Phase II durvalumab + EP, 1L
- Phase 2 LCNEC-ALPINE atezolizumab + EP, 1L
- Phase 1/2 SKYBRIDGE PT217 DLL3/CD47 bispecific ab, 2L+
- Phase 1 LB2102 DLL2-directed CAR T, 2L+

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