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The neoadjuvant/adjuvant pembrolizumab and chemotherapy combination was approved by the FDA in October 2023 for use in this patient population.

Perioperative Pembrolizumab Regimen Upholds Survival Benefit in Resectable NSCLC

Zongertinib demonstrated durable efficacy in patients with pretreated advanced HER2-mutant non–small cell lung cancer.

Zongertinib Elicits Durable Responses in Pretreated Advanced HER2-Mutant NSCLC 

Second-line lenvatinib had clinically meaningful efficacy in patients with advanced HCC after progression on atezolizumab plus bevacizumab.

Lenvatinib Shows Efficacy in Advanced HCC Post-Progression on Atezolizumab/Bevacizumab

The phase 3 TROPiCS-04 study missed its primary end point of improved OS with sacituzumab govitecan vs chemotherapy in patients with urothelial cancer.

Sacituzumab Govitecan Does Not Significantly Improve OS in Pretreated Urothelial Carcinoma

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Articles

The FDA awards accelerated approval to encorafenib regimen in BRAF V600E+ CRC, ensartinib wins approval in ALK+ non–small cell lung cancer, and more.

The OncFive: Top Oncology Articles for the Week of 12/15


Gina Mauro is your lead editorial contact for 

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 in November 2021 as a senior editor and became the website's managing editor in October 2023. Before arriving at MJH Life Sciences, he spent nearly a decade covering professional and high school sports—including the New Jersey Devils and the NHL from 2016 to 2021—for The Star-Ledger and NJ.com. Email: chryan@onclive.com

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Adding dostarlimab to chemotherapy and niraparib maintenance improved progression-free survival in first-line advanced ovarian cancer.

Addition of Dostarlimab to Chemo and Niraparib Maintenance Boosts PFS in Advanced Ovarian Cancer

 as an assistant editor in October 2022. Leveraging an educational background in the life sciences and prior experience conducting interviews in a university setting, she plays a key role in shaping social media strategy, covering live conferences, and producing multimedia content for both print and digital platforms. Email: 

The addition of pegcrisantaspase to venetoclax may overcome resistance to prior BCL-2 inhibitor–based regimens for patients with relapsed/refractory AML. 

Venetoclax Plus PegC May Overcome Resistance to Prior BCL-2 Inhibitors in R/R AML 

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Inside the Clinic: Updates in the Prevention and Treatment of Graft versus Host Disease

Videos

Sophie Paczesny, MD, PhD, and Yi-Bin Chen, MD, discuss recent updates in the prophylactic and treatment strategies for acute and chronic graft versus host disease (GVHD).

Sophie Paczesny, MD, PhD, explains which malignancies allogeneic transplantation can be used as a potentially curative treatment approach, and which patients are best suited for transplant.

Indications for Allogeneic Stem Cell Transplantation in the Treatment of Hematological Malignancies

Dr Sophie Paczesny details the incidence of graft versus host disease (GVHD) in patients receiving allogeneic transplants, and Dr Yi-Bin Chen describes the differing risk factors for acute and chronic GVHD.

Incidence and Risk Factors of Acute and Chronic GVHD

Yi-Bin Chen, MD, shares the most common GVHD prophylaxis regimens, and which regimen he typically chooses for his patients with GVHD.

Common Prophylaxis Regimens for GVHD

Drs Yi-Bin Chen and Sophie Paczesny review the diagnosis and staging of both acute and chronic GVHD, and the challenges clinicians may encounter.

Diagnosis and Stratification of Acute and Chronic GVHD

Experts discuss the current options for treating acute GVHD, including the use of corticosteroids and their management.

Frontline Treatment Options for Acute GVHD

Sophie Paczesny, MD, PhD, and Yi-Bin Chen, MD, detail novel strategies under investigation for the treatment of acute GVHD.

Emerging Strategies for the Treatment of Acute GVHD

Drs Paczesny and Chen explain the importance of treating chronic GVHD as early as possible, and whether steroids are still the standard first-line treatment.

The Importance of Early Treatment of Chronic GVHD

Yi-Bin Chen, MD, reviews the treatment options for patients with steroid-refractory chronic GVHD.

Treatment Options for Steroid-Refractory Chronic GVHD

Drs Yi-Bin Chen and Sophie Paczesny highlight data from key investigational approaches presented at recent meetings.

Key Investigational Approaches for Acute and Chronic GVHD

Sophie Paczesny, MD, PhD, and Yi-Bin Chen, MD, share their expert perspectives on how the GVHD treatment landscape is evolving.

Key Investigational Approaches for Acute and Chronic GVHD

EP: 1.Indications for Allogeneic Stem Cell Transplantation in the Treatment of Hematological Malignancies

EP: 2.Incidence and Risk Factors of Acute and Chronic GVHD

EP: 3.Common Prophylaxis Regimens for GVHD

EP: 4.Diagnosis and Stratification of Acute and Chronic GVHD

EP: 5.Frontline Treatment Options for Acute GVHD

EP: 6.Emerging Strategies for the Treatment of Acute GVHD

EP: 7.The Importance of Early Treatment of Chronic GVHD

EP: 8.Treatment Options for Steroid-Refractory Chronic GVHD

EP: 9.Key Investigational Approaches for Acute and Chronic GVHD

EP: 10.The Evolving Field of GVHD Treatment

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