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Zongertinib demonstrated durable efficacy in patients with pretreated advanced HER2-mutant non–small cell lung cancer.

Zongertinib Elicits Durable Responses in Pretreated Advanced HER2-Mutant NSCLC 

Second-line lenvatinib had clinically meaningful efficacy in patients with advanced HCC after progression on atezolizumab plus bevacizumab.

Lenvatinib Shows Efficacy in Advanced HCC Post-Progression on Atezolizumab/Bevacizumab

The phase 3 TROPiCS-04 study missed its primary end point of improved OS with sacituzumab govitecan vs chemotherapy in patients with urothelial cancer.

Sacituzumab Govitecan Does Not Significantly Improve OS in Pretreated Urothelial Carcinoma

Rates of invasive cancer were noninferior when patients with low-risk ductal carcinoma in situ received active monitoring vs guideline concordant care. 

Active Monitoring Is Noninferior to Guideline Concordant Care in Low-Risk DCIS

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 in November 2021 as a senior editor and became the website's managing editor in October 2023. Before arriving at MJH Life Sciences, he spent nearly a decade covering professional and high school sports—including the New Jersey Devils and the NHL from 2016 to 2021—for The Star-Ledger and NJ.com. Email: chryan@onclive.com

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Adding dostarlimab to chemotherapy and niraparib maintenance improved progression-free survival in first-line advanced ovarian cancer.

Addition of Dostarlimab to Chemo and Niraparib Maintenance Boosts PFS in Advanced Ovarian Cancer

 as an assistant editor in October 2022. Leveraging an educational background in the life sciences and prior experience conducting interviews in a university setting, she plays a key role in shaping social media strategy, covering live conferences, and producing multimedia content for both print and digital platforms. Email: 

The addition of pegcrisantaspase to venetoclax may overcome resistance to prior BCL-2 inhibitor–based regimens for patients with relapsed/refractory AML. 

Venetoclax Plus PegC May Overcome Resistance to Prior BCL-2 Inhibitors in R/R AML 

The FDA has approved encorafenib plus cetuximab and mFOLFOX6 for metastatic colorectal cancer with a BRAF V600E mutation.

FDA Grants Accelerated Approval to Encorafenib Plus Cetuximab and Chemo for BRAF V600E+ Metastatic Colorectal Cancer  

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Retifanlimab represents a promising agent in the squamous cell anal carcinoma field and additional research is needed to improve outcomes for patients.

Filling Unmet Needs in SCAC Is Key as Incidence Rates Are Rising 

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ASK THE EXPERTS: Advanced Neuroimaging of Glioblastoma

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Neuroimaging of Glioblastoma

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Nathalie Albert, MD, and Matthias Preusser, MD, explore the latest advancements in neuroimaging technologies and techniques, focusing on the use of amino acid tracers to enhance the diagnosis, treatment, and overall care of patients with glioblastoma.

Nathalie Albert, MD, and Matthias Preusser, MD engage in an interactive discussion about the primary challenges in neuroimaging for glioblastoma patients and provide an overview of the disease.  

Neuroimaging of Glioblastoma 

Key opinion leaders discuss the patient journey, highlighting the clinical course of the disease and the corresponding imaging needs at each stage, such as identification of biopsy site, delineation of tumor, and differentiation of response from treatment-related effects.  

Navigating Glioblastoma Imaging: The Patient Journey from Diagnosis to Treatment 

Medical experts discuss the use of various neuroimaging techniques, such as MRIs, CT scans, and PET scans, emphasizing that due to limitations of MRI it is frequently combined with other modalities to obtain more comprehensive information.

Leveraging Neuroimaging Modalities and Guidelines in Glioblastoma

Experts engage in a comprehensive discussion on conventional imaging techniques, evaluating the strengths and limitations of CT and MRI scans, particularly in delineating tumor borders and distinguishing between tumors and the surrounding central nervous system tissue.

Conventional Neuroimaging: CT scans & MRI Scans in Glioblastoma

Nathalie Albert, MD, delves into advanced MRI techniques such as perfusion imaging, functional MRI, MR spectroscopy, and DEMARCATE, while also exploring the role of PET imaging, particularly those utilizing glucose and amino acid tracers in neuroimaging.

Advanced Modalities of Neuroimaging in the Management of Glioblastoma

Nathalie Albert, MD, explains that amino acid PET scans can be valuable tools in monitoring disease progression and assessing a patient's response to treatment, while also exploring the optimal timing for utilizing these scans in the overall management of brain tumors.

Polling Question: Utility of Amino Acid PET

Medical experts engage in a discussion on the PET RANO 1.0 Response Criteria, which provides guidelines for evaluating treatment response in patients with brain tumors, taking into account both measurable PET-positive disease and non-PET-positive disease, as assessed through initial baseline imaging and subsequent follow-up scans. 

Implementing PET RANO 1.0 Response Criteria in Glioblastoma Assessment 

Nathalie Albert, MD, and Matthias Preusser, MD, address audience questions and share their insights on promising and anticipated advancements in neuroimaging techniques, highlighting the potential impact of these emerging strategies on the diagnosis, monitoring, and treatment of glioblastoma. 

Q&A: Final Questions on Glioblastoma and Neuroimaging  

Neuroimaging of Glioblastoma

EP: 1.Neuroimaging of Glioblastoma

EP: 2.Navigating Glioblastoma Imaging: The Patient Journey from Diagnosis to Treatment

EP: 3.Leveraging Neuroimaging Modalities and Guidelines in Glioblastoma

EP: 4.Conventional Neuroimaging: CT scans & MRI Scans in Glioblastoma

EP: 5.Advanced Modalities of Neuroimaging in the Management of Glioblastoma

EP: 6.Polling Question: Utility of Amino Acid PET

EP: 7.Implementing PET RANO 1.0 Response Criteria in Glioblastoma Assessment

EP: 8.Q&A: Final Questions on Glioblastoma and Neuroimaging

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