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Opinion|Videos|August 19, 2024

Patient Selection and Sequencing of NSCLC ADCs

Author(s)Mark A. Socinski, MD, Helena A. Yu, MD, Zosia Piotrowska, MD, MHS

The panel examines which patient populations might benefit most from treatment with datopotamab deruxtecan (Dato-DXd), sacituzumab govitecan, and patritumab deruxtecan (HER3-DXd). Additionally, they explore potential sequencing strategies for these antibody-drug conjugates in second-line and later treatment settings.

Episodes in this series

5 KOLs are featured in this peer exchange

EP. 1 Treatment Strategies for NSCLC with Non-Actionable Mutations

5 KOLs are featured in this peer exchange

EP. 2 Role of Antibody-Drug Conjugates in NSCLC Treatment: Insights from EVOKE-02

5 KOLs are featured in this peer exchange

EP. 3 Exploring the TROPION-Lung04 Study

5 KOLs are featured in this peer exchange

EP. 4 Exploring Dato-DXd Combinations as First-Line Therapy for Advanced NSCLC

5 KOLs are featured in this peer exchange

EP. 5 Navigating Between ADCs in NSCLC

5 KOLs are featured in this peer exchange

EP. 6 Advancing Treatment for EGFR-Mutant Advanced NSCLC: Lessons from FLAURA2

5 KOLs are featured in this peer exchange

EP. 7 Osimertinib Monotherapy vs. Combination Therapy: Patient Selection in EGFR-Mutant Advanced NSCLC

5 KOLs are featured in this peer exchange

EP. 8 MARIPOSA Study Insights

5 KOLs are featured in this peer exchange

EP. 9 Optimizing Therapy Selection in EGFR Mutant NSCLC

5 KOLs are featured in this peer exchange

EP. 10 ASCO 2024 Updates: Novel Approaches in NSCLC Therapy

5 KOLs are featured in this peer exchange

EP. 11 Overview of TROP2 & Potential Role of TROP2-Directed ADCs in NSCLC

5 KOLs are featured in this peer exchange

EP. 12 Key Takeaways from TROPION Trials: Implications for NSCLC Treatment Landscape

5 KOLs are featured in this series.

EP. 13 Targeting of HER3: Insights from HERTHENA-Lung01

5 KOLs featured in this series

EP. 14 Challenges and Learnings from EVOKE-01

5 KOLs featured in this series

EP. 15 Key ADC Studies at ASCO 2024

5 KOLs featured in this series

EP. 16 Mitigating Toxicities of Dato-DXd, Sacituzumab Govitecan, and HER3-DXd

5 KOLs featured in this series

EP. 17 Patient Selection and Sequencing of NSCLC ADCs

Discuss which patients are potentially most suitable for:
- Dato-DXd
- Sacituzumab govitecan
- HER3-DXd
With the potential approval of multiple ADCs in second line and beyond, how might these be sequenced in your clinical practice?

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