Targeting of HER3: Insights from HERTHENA-Lung01

Author(s):

Helena A. Yu, MD, initiates a discussion on the role of HER3 in the development of resistance to EGFR-targeted therapies. She also examines the HERTHENA-Lung01 study and analyzes the emerging data from this trial.

EP: 1.Treatment Strategies for NSCLC with Non-Actionable Mutations

EP: 2.Role of Antibody-Drug Conjugates in NSCLC Treatment: Insights from EVOKE-02

EP: 3.Exploring the TROPION-Lung04 Study

EP: 4.Exploring Dato-DXd Combinations as First-Line Therapy for Advanced NSCLC

EP: 5.Navigating Between ADCs in NSCLC

EP: 6.Advancing Treatment for EGFR-Mutant Advanced NSCLC: Lessons from FLAURA2

EP: 7.Osimertinib Monotherapy vs. Combination Therapy: Patient Selection in EGFR-Mutant Advanced NSCLC

EP: 8.MARIPOSA Study Insights

EP: 9.Optimizing Therapy Selection in EGFR Mutant NSCLC

EP: 10.ASCO 2024 Updates: Novel Approaches in NSCLC Therapy

EP: 11.Overview of TROP2 & Potential Role of TROP2-Directed ADCs in NSCLC

EP: 12.Key Takeaways from TROPION Trials: Implications for NSCLC Treatment Landscape

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EP: 13.Targeting of HER3: Insights from HERTHENA-Lung01

EP: 14.Challenges and Learnings from EVOKE-01

EP: 15.Key ADC Studies at ASCO 2024

EP: 16.Mitigating Toxicities of Dato-DXd, Sacituzumab Govitecan, and HER3-DXd

EP: 17.Patient Selection and Sequencing of NSCLC ADCs

Please discuss the role of HER3 in the development of resistance to EGFR targeted therapies. (Manickavasagar, et al. Lung Cancer Mang, 2021; Engelman, et al. Science, 2007)
- Describe the rationale for targeting HER3 in patients with EGFR TKI resistance.
- What have data shown with treatment strategies using dual targeting of HER3 and EGFR?

Please review the rationale and study design for HERTHENA-Lung01 and discuss emerging study data and its implications on the treatment landscape. (Goto, et al. WCLC 2023. Abstract OA05.03; Johnson, et al. ESMO 2023. Abstract 1319MO)
- Briefly outline the study design and key endpoints. What are your perceptions around the brain mets data presented at ESMO this past year?
- What are some key takeaways from safety data?
- What implications may these findings have on clinical practice?