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Third-line Treatment Options for DLBCL After CAR T-cell Therapy or ASCT in Second-line

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Video content above is prompted by the following:

  • Please give an overview of treatment options for a patient who received 2L treatment with either CAR T-cell therapy or ASCT and has relapsed. 
    • What would be your treatment choice in the third line?
    • What key issues do you consider in your sequencing decisions?
    • Please discuss rationales for each:
  • Monoclonal antibody—tafasitamab?
  • ADC —loncastuximab, polatuzumab?
  • Would you go to CAR T after ASCT?
  • Bispecific antibody—epcoritamab or glofitamab?

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