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Opinion|Videos|July 16, 2024

Treatment Decision Making in first-line combinations for advanced RCC

Author(s)Martin H. Voss, MD, Moshe Ornstein, MD

The key opinion leaders explore the various first-line combination treatment options for advanced renal cell carcinoma, including immuno-oncology plus immuno-oncology (IO+IO) and immuno-oncology plus tyrosine kinase inhibitor (IO+TKI) approaches, while also considering the optimal sequencing of treatments to maximize patient benefit.

Episodes in this series

2 KOLs are featured in this series

EP. 1 Evolving Treatment Standards in Non-Clear Cell RCC

2 KOLs are featured in this series

EP. 2 Extended Follow Up of KEYNOTE-B61

2 KOLs are featured in this series

EP. 3 Ongoing Clinical Trials in the front-line setting of advanced non-clear cell RCC

2 KOLs are featured in this series

EP. 4 STELLAR 304: Zanzalintinib plus nivolumab in non-clear cell RCC

2 KOLs are featured in this series

EP. 5 Case Presentation: 61-year-old male Renal Cell Carcinoma

2 KOLs are featured in this series

EP. 6 Use of Combination Regimens in Frontline RCC

2 KOLs are featured in this series

EP. 7 Treatment Decision Making in first-line combinations for advanced RCC

2 KOLs are featured in this series

EP. 8 AE Management for Combination Regimens in Advanced RCC

2 KOLs are featured in this series

EP. 9 AE Management for Combination Regimens in Advanced RCC

2 KOLs are featured in this series

EP. 10 Optimizing Treatment in Advanced RCC

1 KOL is featured in this series.

EP. 11 Dr Albiges Discusses a Non-Clear Cell RCC Patient Profile

1 KOL is featured in this series.

EP. 12 Updates in the Treatment Approach for Non-clear cell RCC

1 KOL is featured in this series.

EP. 13 Dr Albiges Reviews Long term follow up data from KEYNOTE-B61

1 KOL is featured in this series.

EP. 14 Emerging Therapies in the Front-line Setting of Advanced non-clear cell RCC

1 KOL is featured in this series.

EP. 15 Biomarker-driven combination treatment approach in non-clear cell RCC (Met-driven)

1 KOL is featured in this series.

EP. 16 Summary and Forward Looking for RCC

What are the available first-line combination options for advanced RCC?
1. Please discuss your rationale for choosing between IO+IO and IO+TKI approaches and review these data: Network meta-analysis (NMA) – Grunwald, et al. ASCO GU 2024. Abstract 482 –len + pembro vs other 1L treatments in advanced RCC
How do you approach treatment selection in the frontline setting?
1. What factors do you consider when choosing treatment?
2. Which patients do you choose len-pembro versus axi-pembro versus cabo-nivo?

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