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Opinion|Videos|July 8, 2024

Use of Combination Regimens in Frontline RCC

Author(s)Martin H. Voss, MD, Moshe Ornstein, MD

Martin H. Voss, MD, presents data supporting the use of various combination regimens in the frontline treatment of renal cell carcinoma (RCC), focusing on the pivotal trials such as CheckMate 214, KEYNOTE 426, and the CLEAR trial, emphasizing their respective efficacy, safety, and overall impact on the current treatment landscape for RCC patients.

Episodes in this series

2 KOLs are featured in this series

EP. 1 Evolving Treatment Standards in Non-Clear Cell RCC

2 KOLs are featured in this series

EP. 2 Extended Follow Up of KEYNOTE-B61

2 KOLs are featured in this series

EP. 3 Ongoing Clinical Trials in the front-line setting of advanced non-clear cell RCC

2 KOLs are featured in this series

EP. 4 STELLAR 304: Zanzalintinib plus nivolumab in non-clear cell RCC

2 KOLs are featured in this series

EP. 5 Case Presentation: 61-year-old male Renal Cell Carcinoma

2 KOLs are featured in this series

EP. 6 Use of Combination Regimens in Frontline RCC

2 KOLs are featured in this series

EP. 7 Treatment Decision Making in first-line combinations for advanced RCC

2 KOLs are featured in this series

EP. 8 AE Management for Combination Regimens in Advanced RCC

2 KOLs are featured in this series

EP. 9 AE Management for Combination Regimens in Advanced RCC

2 KOLs are featured in this series

EP. 10 Optimizing Treatment in Advanced RCC

1 KOL is featured in this series.

EP. 11 Dr Albiges Discusses a Non-Clear Cell RCC Patient Profile

1 KOL is featured in this series.

EP. 12 Updates in the Treatment Approach for Non-clear cell RCC

1 KOL is featured in this series.

EP. 13 Dr Albiges Reviews Long term follow up data from KEYNOTE-B61

1 KOL is featured in this series.

EP. 14 Emerging Therapies in the Front-line Setting of Advanced non-clear cell RCC

1 KOL is featured in this series.

EP. 15 Biomarker-driven combination treatment approach in non-clear cell RCC (Met-driven)

1 KOL is featured in this series.

EP. 16 Summary and Forward Looking for RCC

Please review data supporting the use of other combination regimens in frontline RCC.
- CheckMate 214 (nivo +ipi): Tannir, et al. ASCO GU 2024. Abstract 363
- KEYNOTE 426 (axi +pembro): Plimack ER, et al. Eur Urol. 2023)
- CLEAR (len+pem vs sunitinib): Viktor Grunwald et. al, ASCO 2024, Abstract 4524

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