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David H. Aggen, MD, PhD, details the evolving landscape of treating patients with urothelial carcinoma.

Navigating a “Sea Change” in Frontline Urothelial Carcinoma Treatment

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Dr Scalici on Data for IMNN-001 Plus SOC Chemotherapy in Advanced Ovarian Cancer

Steven H. Lin, MD, PhD, discusses the safety of NKTR-255 in enhancing immune recovery post-chemoradiation in locally advanced NSCLC.

Dr Lin on the Safety of NKTR-255 in Enhancing Immune Recovery Post-Chemoradiation in Locally Advanced NSCLC

Anna Weiss, MD, discusses the significance of various imaging modalities in patients with breast cancer.

Dr Weiss on the Role of Breast Imaging in Breast Cancer Treatment Decision-Making

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New datopotamab deruxtecan BLA in NSCLC filed to FDA, radiopharmaceutical meets rPFS end point in PSMA+ prostate cancer, and more.

The OncFive: Top Oncology Articles for the Week of 11/10


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The FDA has approved revumenib (Revuforj) for the treatment of adult and pediatric patients aged 1 year and older with relapsed or refractory acute leukemia and a KMT2A translocation.

FDA Approves Revumenib for R/R Acute Leukemia With a KMT2A Translocation

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Brandon G. Smaglo, MD, FACP, discusses ongoing research with novel RAS inhibitors in pancreatic cancer.

Research Aims to Expand RAS Inhibitor Options in Pancreatic Cancer

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Evolving Approaches in the Management of Neuroendocrine Tumor-Associated Carcinoid Syndrome

Videos

Satya (Nanu) Das, MD, MSCI, Rodney Pommier, MD, and Jerome Zacks, MD, discuss how patients with neuroendocrine tumors progress to carcinoid syndrome and carcinoid heart disease, and how strategies for management have changed after key clinical trial data.

Funding provided by TerSera Therapeutics LLC. Content independently developed by OncLive.

Satya (Nanu) Das, MD, MSCI, provides an overview of the incidence rate and common symptoms of neuroendocrine tumors (NETs).

Overview of Neuroendocrine Tumors (NETs)

Rodney Pommier, MD, defines carcinoid syndrome and describes the process of diagnosis and clinical risk factors in patients.

Overview of Carcinoid Syndrome (CS)

Jerome Zacks, MD, explains carcinoid heart disease and its symptoms, and why it develops in some patients with NET-associated carcinoid syndrome.

Overview of Carcinoid Heart Disease (CHD)

Dr Satya (Nanu) Das discusses the typical management strategies for carcinoid syndrome-related symptoms, highlighting the use of somatostatin analogs.

Management of Carcinoid Syndrome-Related Symptoms

Dr Rodney Pommier gives an overview of somatostatin analog-refractory carcinoid syndrome and the recommended approaches for management in patients.

Diagnosis and Management of Somatostatin Analog-Refractory Carcinoid Syndrome

A medical oncologist reviews the currently available, NCCN-approved treatments for somatostatin analog-refractory carcinoid syndrome.

Available Treatment Options for Somatostatin Analog-Refractory Carcinoid Syndrome

Dr Pommier discusses key safety, efficacy, and quality of life data from the TELEPATH trial investigating the tryptophan hydroxylase inhibitor telotristat ethyl, while Dr Das comments on real-world data complements to the trial.

Data from the TELEPATH Trial and Real-World Analyses

Dr Jerome Zacks explains strategies to prevent, treat, and manage carcinoid heart disease, and emphasizes the need for multidisciplinary approaches.

Prevention, Treatment, and Management of Carcinoid Heart Disease

Experts comment on the current unmet needs for patients with neuroendocrine tumor-associated carcinoid syndrome.

Unmet Needs for Patients with Neuroendocrine Tumor-Associated Carcinoid Syndrome

Drs Das, Pommier, and Zacks share their advice for community physicians treating patients who have neuroendocrine tumors with carcinoid syndrome and carcinoid heart disease.

Advice for Community Physicians Treating Patients with Neuroendocrine Tumor-Associated Carcinoid Syndrome

EP: 1.Overview of Neuroendocrine Tumors (NETs)

EP: 2.Overview of Carcinoid Syndrome (CS)

EP: 3.Overview of Carcinoid Heart Disease (CHD)

EP: 4.Management of Carcinoid Syndrome-Related Symptoms

EP: 5.Diagnosis and Management of Somatostatin Analog-Refractory Carcinoid Syndrome

EP: 6.Available Treatment Options for Somatostatin Analog-Refractory Carcinoid Syndrome

EP: 7.Data from the TELEPATH Trial and Real-World Analyses

EP: 8.Prevention, Treatment, and Management of Carcinoid Heart Disease

EP: 9.Unmet Needs for Patients with Neuroendocrine Tumor-Associated Carcinoid Syndrome

EP: 10.Advice for Community Physicians Treating Patients with Neuroendocrine Tumor-Associated Carcinoid Syndrome

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