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J. Bradley Elder, MD, discusses blinded early-safety data from a phase 2b trial of IGV-001 in patients with newly diagnosed glioblastoma.

Dr Elder on the Initial Safety Profile of IGV-001 in Newly Diagnosed Glioblastoma

Rimas V. Lukas, MD, discusses the efficacy of eflornithine plus lomustine in recurrent IDH-mutant anaplastic astrocytoma per 2021 WHO diagnostic criteria.

Dr Lukas on Survival Outcomes With Eflornithine in IDH-Mutant Anaplastic Astrocytoma 

IGV-001, an autologous cell immunotherapy, demonstrated an acceptable safety profile in patients with newly diagnosed glioblastoma.

IGV-001 Showcases Positive Benefit-Risk Profile in Newly Diagnosed Glioblastoma

Diane Reidy-Lagunes, MD, discusses key trials that have expanded the treatment paradigm for patients with neuroendocrine tumors.

Dr Reidy-Lagunes on the Evolving NET Treatment Paradigm

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Articles

Zanidatamab scores approval for HER2+ biliary tract cancer, Versamune HPV is under exploration in HPV16+ head and neck squamous cell carcinoma, and more.

The OncFive: Top Oncology Articles for the Week of 11/17


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Jairam Krishnamurthy, MD, FACP, details what to take into consideration when implementing 2024 Breast Cancer NCCN guideline changes into everyday practice. 

Category 1 Recommendation of Ribociclib Plus an AI Represents Huge Advancement in Breast Cancer

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Francisco J. Esteva, MD, PhD, highlights various pivotal studies for the treatment of HER2-positive early-stage breast cancer.

Long-Term Findings Solidify Role of HER2-Targeted Therapy in Early HER2+ Breast Cancer

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Evolving Approaches in the Management of Neuroendocrine Tumor-Associated Carcinoid Syndrome

Videos

Satya (Nanu) Das, MD, MSCI, Rodney Pommier, MD, and Jerome Zacks, MD, discuss how patients with neuroendocrine tumors progress to carcinoid syndrome and carcinoid heart disease, and how strategies for management have changed after key clinical trial data.

Funding provided by TerSera Therapeutics LLC. Content independently developed by OncLive.

Satya (Nanu) Das, MD, MSCI, provides an overview of the incidence rate and common symptoms of neuroendocrine tumors (NETs).

Overview of Neuroendocrine Tumors (NETs)

Rodney Pommier, MD, defines carcinoid syndrome and describes the process of diagnosis and clinical risk factors in patients.

Overview of Carcinoid Syndrome (CS)

Jerome Zacks, MD, explains carcinoid heart disease and its symptoms, and why it develops in some patients with NET-associated carcinoid syndrome.

Overview of Carcinoid Heart Disease (CHD)

Dr Satya (Nanu) Das discusses the typical management strategies for carcinoid syndrome-related symptoms, highlighting the use of somatostatin analogs.

Management of Carcinoid Syndrome-Related Symptoms

Dr Rodney Pommier gives an overview of somatostatin analog-refractory carcinoid syndrome and the recommended approaches for management in patients.

Diagnosis and Management of Somatostatin Analog-Refractory Carcinoid Syndrome

A medical oncologist reviews the currently available, NCCN-approved treatments for somatostatin analog-refractory carcinoid syndrome.

Available Treatment Options for Somatostatin Analog-Refractory Carcinoid Syndrome

Dr Pommier discusses key safety, efficacy, and quality of life data from the TELEPATH trial investigating the tryptophan hydroxylase inhibitor telotristat ethyl, while Dr Das comments on real-world data complements to the trial.

Data from the TELEPATH Trial and Real-World Analyses

Dr Jerome Zacks explains strategies to prevent, treat, and manage carcinoid heart disease, and emphasizes the need for multidisciplinary approaches.

Prevention, Treatment, and Management of Carcinoid Heart Disease

Experts comment on the current unmet needs for patients with neuroendocrine tumor-associated carcinoid syndrome.

Unmet Needs for Patients with Neuroendocrine Tumor-Associated Carcinoid Syndrome

Drs Das, Pommier, and Zacks share their advice for community physicians treating patients who have neuroendocrine tumors with carcinoid syndrome and carcinoid heart disease.

Overview of Neuroendocrine Tumors (NETs)

EP: 1.Overview of Neuroendocrine Tumors (NETs)

EP: 2.Overview of Carcinoid Syndrome (CS)

EP: 3.Overview of Carcinoid Heart Disease (CHD)

EP: 4.Management of Carcinoid Syndrome-Related Symptoms

EP: 5.Diagnosis and Management of Somatostatin Analog-Refractory Carcinoid Syndrome

EP: 6.Available Treatment Options for Somatostatin Analog-Refractory Carcinoid Syndrome

EP: 7.Data from the TELEPATH Trial and Real-World Analyses

EP: 8.Prevention, Treatment, and Management of Carcinoid Heart Disease

EP: 9.Unmet Needs for Patients with Neuroendocrine Tumor-Associated Carcinoid Syndrome

EP: 10.Advice for Community Physicians Treating Patients with Neuroendocrine Tumor-Associated Carcinoid Syndrome

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