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The neoadjuvant/adjuvant pembrolizumab and chemotherapy combination was approved by the FDA in October 2023 for use in this patient population.

Perioperative Pembrolizumab Regimen Upholds Survival Benefit in Resectable NSCLC

Zongertinib demonstrated durable efficacy in patients with pretreated advanced HER2-mutant non–small cell lung cancer.

Zongertinib Elicits Durable Responses in Pretreated Advanced HER2-Mutant NSCLC 

Second-line lenvatinib had clinically meaningful efficacy in patients with advanced HCC after progression on atezolizumab plus bevacizumab.

Lenvatinib Shows Efficacy in Advanced HCC Post-Progression on Atezolizumab/Bevacizumab

The phase 3 TROPiCS-04 study missed its primary end point of improved OS with sacituzumab govitecan vs chemotherapy in patients with urothelial cancer.

Sacituzumab Govitecan Does Not Significantly Improve OS in Pretreated Urothelial Carcinoma

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The FDA awards accelerated approval to encorafenib regimen in BRAF V600E+ CRC, ensartinib wins approval in ALK+ non–small cell lung cancer, and more.

The OncFive: Top Oncology Articles for the Week of 12/15


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Adding dostarlimab to chemotherapy and niraparib maintenance improved progression-free survival in first-line advanced ovarian cancer.

Addition of Dostarlimab to Chemo and Niraparib Maintenance Boosts PFS in Advanced Ovarian Cancer

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The addition of pegcrisantaspase to venetoclax may overcome resistance to prior BCL-2 inhibitor–based regimens for patients with relapsed/refractory AML. 

Venetoclax Plus PegC May Overcome Resistance to Prior BCL-2 Inhibitors in R/R AML 

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Evolving Approaches in the Management of Neuroendocrine Tumor-Associated Carcinoid Syndrome

Videos

Satya (Nanu) Das, MD, MSCI, Rodney Pommier, MD, and Jerome Zacks, MD, discuss how patients with neuroendocrine tumors progress to carcinoid syndrome and carcinoid heart disease, and how strategies for management have changed after key clinical trial data.

Funding provided by TerSera Therapeutics LLC. Content independently developed by OncLive.

Satya (Nanu) Das, MD, MSCI, provides an overview of the incidence rate and common symptoms of neuroendocrine tumors (NETs).

Overview of Neuroendocrine Tumors (NETs)

Rodney Pommier, MD, defines carcinoid syndrome and describes the process of diagnosis and clinical risk factors in patients.

Overview of Carcinoid Syndrome (CS)

Jerome Zacks, MD, explains carcinoid heart disease and its symptoms, and why it develops in some patients with NET-associated carcinoid syndrome.

Overview of Carcinoid Heart Disease (CHD)

Dr Satya (Nanu) Das discusses the typical management strategies for carcinoid syndrome-related symptoms, highlighting the use of somatostatin analogs.

Management of Carcinoid Syndrome-Related Symptoms

Dr Rodney Pommier gives an overview of somatostatin analog-refractory carcinoid syndrome and the recommended approaches for management in patients.

Diagnosis and Management of Somatostatin Analog-Refractory Carcinoid Syndrome

A medical oncologist reviews the currently available, NCCN-approved treatments for somatostatin analog-refractory carcinoid syndrome.

Available Treatment Options for Somatostatin Analog-Refractory Carcinoid Syndrome

Dr Pommier discusses key safety, efficacy, and quality of life data from the TELEPATH trial investigating the tryptophan hydroxylase inhibitor telotristat ethyl, while Dr Das comments on real-world data complements to the trial.

Data from the TELEPATH Trial and Real-World Analyses

Dr Jerome Zacks explains strategies to prevent, treat, and manage carcinoid heart disease, and emphasizes the need for multidisciplinary approaches.

Prevention, Treatment, and Management of Carcinoid Heart Disease

Experts comment on the current unmet needs for patients with neuroendocrine tumor-associated carcinoid syndrome.

Unmet Needs for Patients with Neuroendocrine Tumor-Associated Carcinoid Syndrome

Drs Das, Pommier, and Zacks share their advice for community physicians treating patients who have neuroendocrine tumors with carcinoid syndrome and carcinoid heart disease.

Available Treatment Options for Somatostatin Analog-Refractory Carcinoid Syndrome

EP: 1.Overview of Neuroendocrine Tumors (NETs)

EP: 2.Overview of Carcinoid Syndrome (CS)

EP: 3.Overview of Carcinoid Heart Disease (CHD)

EP: 4.Management of Carcinoid Syndrome-Related Symptoms

EP: 5.Diagnosis and Management of Somatostatin Analog-Refractory Carcinoid Syndrome

EP: 6.Available Treatment Options for Somatostatin Analog-Refractory Carcinoid Syndrome

EP: 7.Data from the TELEPATH Trial and Real-World Analyses

EP: 8.Prevention, Treatment, and Management of Carcinoid Heart Disease

EP: 9.Unmet Needs for Patients with Neuroendocrine Tumor-Associated Carcinoid Syndrome

EP: 10.Advice for Community Physicians Treating Patients with Neuroendocrine Tumor-Associated Carcinoid Syndrome

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