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The neoadjuvant/adjuvant pembrolizumab and chemotherapy combination was approved by the FDA in October 2023 for use in this patient population.

Perioperative Pembrolizumab Regimen Upholds Survival Benefit in Resectable NSCLC

Zongertinib demonstrated durable efficacy in patients with pretreated advanced HER2-mutant non–small cell lung cancer.

Zongertinib Elicits Durable Responses in Pretreated Advanced HER2-Mutant NSCLC 

Second-line lenvatinib had clinically meaningful efficacy in patients with advanced HCC after progression on atezolizumab plus bevacizumab.

Lenvatinib Shows Efficacy in Advanced HCC Post-Progression on Atezolizumab/Bevacizumab

The phase 3 TROPiCS-04 study missed its primary end point of improved OS with sacituzumab govitecan vs chemotherapy in patients with urothelial cancer.

Sacituzumab Govitecan Does Not Significantly Improve OS in Pretreated Urothelial Carcinoma

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Articles

The FDA awards accelerated approval to encorafenib regimen in BRAF V600E+ CRC, ensartinib wins approval in ALK+ non–small cell lung cancer, and more.

The OncFive: Top Oncology Articles for the Week of 12/15


Gina Mauro is your lead editorial contact for 

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. Prior to joining MJH Life Sciences, she worked at Gannett as a full-time reporter with the Asbury Park Press. Email: gmauro@onclive.com 

 
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 in November 2021 as a senior editor and became the website's managing editor in October 2023. Before arriving at MJH Life Sciences, he spent nearly a decade covering professional and high school sports—including the New Jersey Devils and the NHL from 2016 to 2021—for The Star-Ledger and NJ.com. Email: chryan@onclive.com

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Adding dostarlimab to chemotherapy and niraparib maintenance improved progression-free survival in first-line advanced ovarian cancer.

Addition of Dostarlimab to Chemo and Niraparib Maintenance Boosts PFS in Advanced Ovarian Cancer

 as an assistant editor in October 2022. Leveraging an educational background in the life sciences and prior experience conducting interviews in a university setting, she plays a key role in shaping social media strategy, covering live conferences, and producing multimedia content for both print and digital platforms. Email: 

The addition of pegcrisantaspase to venetoclax may overcome resistance to prior BCL-2 inhibitor–based regimens for patients with relapsed/refractory AML. 

Venetoclax Plus PegC May Overcome Resistance to Prior BCL-2 Inhibitors in R/R AML 

OncLive serves as the connection to oncology, including groundbreaking cancer news and interviews with top oncologists in multimedia formats.

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My Treatment Approach: Graft vs Host Disease

Videos

Nelson J. Chao, MD, MBA, discusses the treatment of acute and chronic graft-versus-host disease through the lens of two patient profiles.

Nelson J. Chao, MD, MBA, presents the patient profile of a 60-year-old man with chronic myeloid leukemia and graft-versus-host disease (GVHD) and shares his initial impressions.

Patient Profile Presentation: A 60-Year-Old Man with Graft-Versus-Host Disease (GVHD)				

Dr Nelson J. Chao reviews how chronic graft-versus-host disease is diagnosed and staged, and the importance of multidisciplinary team communication.

Staging of Chronic GVHD

Nelson J. Chao, MD, MBA, explains the frontline treatment options for chronic GVHD, and when to consider restarting an immunosuppressive regimen.

First-Line Treatment Options for Patients with Chronic GVHD

Dr Nelson J. Chao presents the patient profile of a 67-year-old woman with chronic graft-versus-host disease after a bone marrow donation from a multiparous female.

Patient Profile Presentation: A 67-Year-Old Woman with GVHD

Nelson J. Chao, MD, MBA, details some novel agents being developed for the systemic treatment of GVHD, particularly chronic GVHD.

Investigational Systemic Treatment Options for GVHD

Dr Nelson J. Chao reviews treatment sequencing and speculates on the future of the GVHD treatment landscape.

Treatment Sequencing and Future of GVHD

Pashna Munshi, MD, presents the patient profile of a 44-year-old woman with acute myeloid leukemia diagnosed with grade 2 skin acute GVHD, and shares her initial impressions and what she might have done differently.

Patient Profile Presentation: A 44-Year-Old Woman With Acute Myeloid Leukemia and Graft-Versus-Host Disease (GVHD)

Dr Pashna Munshi describes for what myeloid malignancies allogeneic transplantation is indicated, and its curative potential.

Indications for Allogeneic Stem Cell Transplantation in the Treatment of Myeloid Malignancies

Pashna Munshi, MD, details how age and risk factors into her choice of conditioning regimen for patients with GVHD receiving allogeneic transplant.

Tailored Conditioning Regimens for Patients with GVHD Receiving Allogeneic Transplant

Dr Pashna Munshi explains the currently available options for GVHD prophylaxis and which regimens she utilizes the most in her clinical practice.

Currently Available Options for GVHD Prophylaxis

Pashna Munshi, MD, reviews the differences between acute and chronic GVHD.

Comparing Acute and Chronic GVHD

Pashna Munshi, MD, discusses how acute GVHD is staged and graded, and the common frontline treatment options.

Available Frontline Treatment Options for Patients With Acute GVHD

Closing her discussion, Dr Pashna Munshi reviews recent data on the available treatment options for patients with steroid-refractory acute GVHD.

Available Frontline Treatment Options for Patients With Acute GVHD

EP: 1.Patient Profile Presentation: A 60-Year-Old Man with Graft-Versus-Host Disease (GVHD)

EP: 2.Staging of Chronic GVHD

EP: 3.First-Line Treatment Options for Patients with Chronic GVHD

EP: 4.Patient Profile Presentation: A 67-Year-Old Woman with GVHD

EP: 5.Investigational Systemic Treatment Options for GVHD

EP: 6.Treatment Sequencing and Future of GVHD

EP: 7.Patient Profile Presentation: A 44-Year-Old Woman With Acute Myeloid Leukemia and Graft-Versus-Host Disease (GVHD)

EP: 8.Indications for Allogeneic Stem Cell Transplantation in the Treatment of Myeloid Malignancies

EP: 9.Tailored Conditioning Regimens for Patients with GVHD Receiving Allogeneic Transplant

EP: 10.Currently Available Options for GVHD Prophylaxis

EP: 11.Comparing Acute and Chronic GVHD

EP: 12.Available Frontline Treatment Options for Patients With Acute GVHD

EP: 13.Current Treatment Options for Patients with Steroid-Refractory Acute GVHD

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