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DK210 (EGFR) showed evidence of wild-type IL-2 signaling, CRS mitigation, and immune response signaling in patients with solid tumors. 

DK210 (EGFR) Induces Immune Response Without Increased CRS or Regulatory T Cells in Solid Tumors

Siglec-15 was expressed in tumor cells and tumor-associated macrophages in tissue samples from non–small cell lung cancer and other solid tumors.

Siglec-15 Represents Potential Therapeutic Target in NSCLC, Other Solid Tumors

Radiomic biomarkers can predict treatment response through assessments of tumor growth in patients with metastatic uveal melanoma treated with roginolisib.

Radiomic Biomarkers Predict Response in Lung and Liver Uveal Melanoma Metastases

The Nectin-4/CD137 Bicycle–targeted immune cell agonist BT7480 had antitumor activity in patients with Nectin-4– and CD137-expressing tumors. 

BT7480 Shows Preliminary Activity in Nectin-4+, CD137+ Tumors 

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 in November 2021 as a senior editor and became the website's managing editor in October 2023. Before arriving at MJH Life Sciences, he spent nearly a decade covering professional and high school sports—including the New Jersey Devils and the NHL from 2016 to 2021—for The Star-Ledger and NJ.com. Email: chryan@onclive.com

Articles

The Immune Profile Score algorithmic test is now available for clinical use as a prognostic tool for immune checkpoint inhibitors in solid tumors.

Immune Profile Score Algorithmic Test Is Now Available to Help Inform Checkpoint Inhibitor Use in Cancer 

Kevin Kalinsky, MD, MS, discusses his top takeaways from the 2024 ASCO Annual Meeting and 2024 ESMO Congress, as well as where he sees the field of breast cancer evolving into the future. 

Explore Emerging Breast Cancer Treatment Trends With Kevin Kalinsky, MD, MS

 as an assistant editor in October 2022. Leveraging an educational background in the life sciences and prior experience conducting interviews in a university setting, she plays a key role in shaping social media strategy, covering live conferences, and producing multimedia content for both print and digital platforms. Email: 

OncLive serves as the connection to oncology, including groundbreaking cancer news and interviews with top oncologists in multimedia formats.

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My Treatment Approach: Graft vs Host Disease

Videos

Nelson J. Chao, MD, MBA, discusses the treatment of acute and chronic graft-versus-host disease through the lens of two patient profiles.

Nelson J. Chao, MD, MBA, presents the patient profile of a 60-year-old man with chronic myeloid leukemia and graft-versus-host disease (GVHD) and shares his initial impressions.

Patient Profile Presentation: A 60-Year-Old Man with Graft-Versus-Host Disease (GVHD)				

Dr Nelson J. Chao reviews how chronic graft-versus-host disease is diagnosed and staged, and the importance of multidisciplinary team communication.

Staging of Chronic GVHD

Nelson J. Chao, MD, MBA, explains the frontline treatment options for chronic GVHD, and when to consider restarting an immunosuppressive regimen.

First-Line Treatment Options for Patients with Chronic GVHD

Dr Nelson J. Chao presents the patient profile of a 67-year-old woman with chronic graft-versus-host disease after a bone marrow donation from a multiparous female.

Patient Profile Presentation: A 67-Year-Old Woman with GVHD

Nelson J. Chao, MD, MBA, details some novel agents being developed for the systemic treatment of GVHD, particularly chronic GVHD.

Investigational Systemic Treatment Options for GVHD

Dr Nelson J. Chao reviews treatment sequencing and speculates on the future of the GVHD treatment landscape.

Treatment Sequencing and Future of GVHD

Pashna Munshi, MD, presents the patient profile of a 44-year-old woman with acute myeloid leukemia diagnosed with grade 2 skin acute GVHD, and shares her initial impressions and what she might have done differently.

Patient Profile Presentation: A 44-Year-Old Woman With Acute Myeloid Leukemia and Graft-Versus-Host Disease (GVHD)

Dr Pashna Munshi describes for what myeloid malignancies allogeneic transplantation is indicated, and its curative potential.

Indications for Allogeneic Stem Cell Transplantation in the Treatment of Myeloid Malignancies

Pashna Munshi, MD, details how age and risk factors into her choice of conditioning regimen for patients with GVHD receiving allogeneic transplant.

Tailored Conditioning Regimens for Patients with GVHD Receiving Allogeneic Transplant

Dr Pashna Munshi explains the currently available options for GVHD prophylaxis and which regimens she utilizes the most in her clinical practice.

Currently Available Options for GVHD Prophylaxis

Pashna Munshi, MD, reviews the differences between acute and chronic GVHD.

Comparing Acute and Chronic GVHD

Pashna Munshi, MD, discusses how acute GVHD is staged and graded, and the common frontline treatment options.

Available Frontline Treatment Options for Patients With Acute GVHD

Closing her discussion, Dr Pashna Munshi reviews recent data on the available treatment options for patients with steroid-refractory acute GVHD.

Current Treatment Options for Patients with Steroid-Refractory Acute GVHD

Insights Video Series

Comparing Acute and Chronic GVHD

EP: 1.Patient Profile Presentation: A 60-Year-Old Man with Graft-Versus-Host Disease (GVHD)

EP: 2.Staging of Chronic GVHD

EP: 3.First-Line Treatment Options for Patients with Chronic GVHD

EP: 4.Patient Profile Presentation: A 67-Year-Old Woman with GVHD

EP: 5.Investigational Systemic Treatment Options for GVHD

EP: 6.Treatment Sequencing and Future of GVHD

EP: 7.Patient Profile Presentation: A 44-Year-Old Woman With Acute Myeloid Leukemia and Graft-Versus-Host Disease (GVHD)

EP: 8.Indications for Allogeneic Stem Cell Transplantation in the Treatment of Myeloid Malignancies

EP: 9.Tailored Conditioning Regimens for Patients with GVHD Receiving Allogeneic Transplant

EP: 10.Currently Available Options for GVHD Prophylaxis

EP: 11.Comparing Acute and Chronic GVHD

EP: 12.Available Frontline Treatment Options for Patients With Acute GVHD

EP: 13.Current Treatment Options for Patients with Steroid-Refractory Acute GVHD

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