Expert Perspectives & Insights into CAR T-cell Therapy in Relapsed / Refractory Acute Lymphoblastic Leukemia : Episode 2
Opinion
Video
CAR T-cell Therapy: Mechanisms of Actions of Brexucabtagene Autoleucel and Obecabtagene Autoleucel
Author(s):
Dr. Lori Muffly explains the general mechanism of action in CAR T-cell therapy and compares the distinct features of Brexucabtagene autoleucel (Brexu-cel), Tisagenlecleucel (Tisa-cel), and Obecabtagene autoleucel (Obe-cel).
- Dr. Jabbour to Dr. Muffly: What is the general mechanism of CAR T-cell therapy? What are the differences between the various CAR-Ts Brexucabtageneautoleucel (Brexu-cel), Tisagenlecleucel (Tisa-cel), and Obecabtageneautoleucel (Obe-cel)?
- Brexu-cel & Tisa-cel CAR-T Construct Design
- Obe-Cel CAT19-41BB-Z Fast Off Rate Design
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