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Opinion|Videos|December 20, 2024

Managing T315I Mutations in CML: Second Line Treatment Options - Ponatinib & Asciminib

Author(s)Jorge Cortes, MD, Stephen A. Strickland, MD, MSCI

Panelists discuss how for patients with chronic myeloid leukemia who develop the T315I mutation, ponatinib and asciminib have demonstrated efficacy in the PACE and ASCEMBL trials, respectively, with ponatinib showing a major cytogenetic response rate in patients with T315I mutation and asciminib demonstrating superior major molecular response vs bosutinib.

Episodes in this series

2 experts in this video

EP. 1 Evaluating Early Treatment Response in CML: Expert Insights on Monitoring

2 experts in this video

EP. 2 Interpreting Milestones: Prioritizing the Patient Picture

2 experts in this video

EP. 3 Managing T315I Mutations in CML: Second Line Treatment Options - Ponatinib & Asciminib

2 experts in this video

EP. 4 Beyond T315I mutations: When to Consider Ponatinib or Asciminib in CML Second-Line Treatment

2 experts in this video

EP. 5 Managing Adverse Events: Ponatinib & Asciminib in CML: Expert Approaches

2 experts in this video

EP. 6 Choosing First-Line TKI Therapy for CML: Expert Approaches to Risk Assessment & Treatment Selection

2 experts in this video

EP. 7 ASC4FIRST Trial & Asciminib New FDA Approval: Evaluating Asciminib in First-Line CML Treatment

2 experts in this video

EP. 8 Key Takeaways: The Current Landscape and Future of CML Care

Video content above is prompted by the following:

We know that a T315I mutation in the kinase domain confers resistance to our frontline therapies for chronic myeloid leukemia (bosutinib, dasatinib, imatinib, and nilotinib). What therapies are available for patients who develop this mutation while taking their first-line tyrosine kinase inhibitor?
- Please briefly review the ASCEMBL and PACE trials and key outcomes.

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