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Opinion|Videos|January 3, 2025

Managing Adverse Events: Ponatinib & Asciminib in CML: Expert Approaches

Author(s)Jorge Cortes, MD, Stephen A. Strickland, MD, MSCI

Panelists discuss how clinicians should implement regular cardiovascular monitoring and dose modifications for ponatinib-associated toxicities while being vigilant for asciminib’s key adverse events, including thrombocytopenia, pancreatic dysfunction, and hypertension, with appropriate dose adjustments and supportive care as needed.

Episodes in this series

2 experts in this video

EP. 1 Evaluating Early Treatment Response in CML: Expert Insights on Monitoring

2 experts in this video

EP. 2 Interpreting Milestones: Prioritizing the Patient Picture

2 experts in this video

EP. 3 Managing T315I Mutations in CML: Second Line Treatment Options - Ponatinib & Asciminib

2 experts in this video

EP. 4 Beyond T315I mutations: When to Consider Ponatinib or Asciminib in CML Second-Line Treatment

2 experts in this video

EP. 5 Managing Adverse Events: Ponatinib & Asciminib in CML: Expert Approaches

2 experts in this video

EP. 6 Choosing First-Line TKI Therapy for CML: Expert Approaches to Risk Assessment & Treatment Selection

2 experts in this video

EP. 7 ASC4FIRST Trial & Asciminib New FDA Approval: Evaluating Asciminib in First-Line CML Treatment

2 experts in this video

EP. 8 Key Takeaways: The Current Landscape and Future of CML Care

Video content above is prompted by the following:

What is your approach to monitoring and managing cardiovascular toxicities associated with ponatinib?
What adverse events should clinicians be aware of with asciminib, and what is your approach to monitoring and managing these?

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