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Opinion|Videos|January 10, 2025

ASC4FIRST Trial & Asciminib New FDA Approval: Evaluating Asciminib in First-Line CML Treatment

Author(s)Jorge Cortes, MD, Stephen A. Strickland, MD, MSCI

Panelists discuss how a clinician seeks guidance on implementing asciminib in first-line chronic myeloid leukemia treatment following its FDA approval, including understanding its trial data and determining appropriate patient selection compared with existing tyrosine kinase inhibitor options.

Episodes in this series

2 experts in this video

EP. 1 Evaluating Early Treatment Response in CML: Expert Insights on Monitoring

2 experts in this video

EP. 2 Interpreting Milestones: Prioritizing the Patient Picture

2 experts in this video

EP. 3 Managing T315I Mutations in CML: Second Line Treatment Options - Ponatinib & Asciminib

2 experts in this video

EP. 4 Beyond T315I mutations: When to Consider Ponatinib or Asciminib in CML Second-Line Treatment

2 experts in this video

EP. 5 Managing Adverse Events: Ponatinib & Asciminib in CML: Expert Approaches

2 experts in this video

EP. 6 Choosing First-Line TKI Therapy for CML: Expert Approaches to Risk Assessment & Treatment Selection

2 experts in this video

EP. 7 ASC4FIRST Trial & Asciminib New FDA Approval: Evaluating Asciminib in First-Line CML Treatment

2 experts in this video

EP. 8 Key Takeaways: The Current Landscape and Future of CML Care

Video content above is prompted by the following:

Can you tell us about the trial design, key end points, and your impressions of the data?
With the recent FDA approval of asciminib in the first-line (1L) setting, how will you incorporate this into your practice?
- Are there particular patients whom you would consider for asciminib vs first- or second-generation tyrosine kinase inhibitors?
Please share any anticipated similarities or differences in your clinical practice now that asciminib has received FDA approval in the 1L setting.

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