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Opinion|Videos|December 11, 2024

Challenges With Defining “Ruxolitinib Failure” or Suboptimal Response to Ruxolitinib in MF

Author(s)Andrew Kuykendall, MD, Venu Konala, MD

Panelists discuss how they define “ruxolitinib failure” and a suboptimal response, when they consider switching from first-line ruxolitinib, and how they differentiate between myelofibrosis-induced and JAK-induced cytopenias.

Episodes in this series

EP. 1 Clinical Perspectives: Firstline Treatment Landscape in Higher-Risk MF

EP. 1 Clinical Perspectives: Firstline Treatment Landscape in Higher-Risk MF

EP. 2 Tackling Complex Clinical Scenarios: MF Patients With Thrombocytopenia and Anemia

EP. 2 Tackling Complex Clinical Scenarios: MF Patients With Thrombocytopenia and Anemia

EP. 3 Challenges With Defining “Ruxolitinib Failure” or Suboptimal Response to Ruxolitinib in MF

EP. 3 Challenges With Defining “Ruxolitinib Failure” or Suboptimal Response to Ruxolitinib in MF

EP. 4 Clinical Insights on Managing Ruxolitinib Cytopenias: Patient-Focused Approach

EP. 4 Clinical Insights on Managing Ruxolitinib Cytopenias: Patient-Focused Approach

EP. 5 Practice Takeaways: Treating MF Patients—Key Strategies for Community Providers

EP. 5 Practice Takeaways: Treating MF Patients—Key Strategies for Community Providers

Dr Kuykendall to Dr Konala: Switching gears a bit, Dr Konala: How do you define “ruxolitinib failure?” What is a suboptimal response, in your clinical opinion?
Dr Kuykendall: Please comment on your threshold or when you might consider switching from first-line ruxolitinib and how you differentiate myelofibrosis-induced cytopenias (anemia or thrombocytopenia) from JAK-induced cytopenias.

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