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Opinion|Videos|December 18, 2024

Clinical Insights on Managing Ruxolitinib Cytopenias: Patient-Focused Approach

Author(s)Andrew Kuykendall, MD, Venu Konala, MD

Panelists discuss the patient and disease characteristics influencing the decision to dose-reduce ruxolitinib vs switching therapy. They share their typical sequencing approach after first-line ruxolitinib, including whether a washout period or overlap is required.

Episodes in this series

EP. 1 Clinical Perspectives: Firstline Treatment Landscape in Higher-Risk MF

EP. 1 Clinical Perspectives: Firstline Treatment Landscape in Higher-Risk MF

EP. 2 Tackling Complex Clinical Scenarios: MF Patients With Thrombocytopenia and Anemia

EP. 2 Tackling Complex Clinical Scenarios: MF Patients With Thrombocytopenia and Anemia

EP. 3 Challenges With Defining “Ruxolitinib Failure” or Suboptimal Response to Ruxolitinib in MF

EP. 3 Challenges With Defining “Ruxolitinib Failure” or Suboptimal Response to Ruxolitinib in MF

EP. 4 Clinical Insights on Managing Ruxolitinib Cytopenias: Patient-Focused Approach

EP. 4 Clinical Insights on Managing Ruxolitinib Cytopenias: Patient-Focused Approach

EP. 5 Practice Takeaways: Treating MF Patients—Key Strategies for Community Providers

EP. 5 Practice Takeaways: Treating MF Patients—Key Strategies for Community Providers

Dr Kuykendall to Dr Konala: What patient and/or disease characteristics do you consider when deciding to dose-reduce ruxolitinib vs change therapy? How do you take into account your patient’s preference in this situation?
Dr Kuykendall: Please share your typical sequencing approach post first-line ruxolitinib. What does the process look like? Does it require a washout period or overlap?

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