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as well as news and conference updates for OncLive.com. Email: kdoherty@mjhlifesciences.com

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Clinical Insights in Myelofibrosis: Addressing Unmet Needs & Advancing Outcomes 

Practice Takeaways: Treating MF Patients—Key Strategies for Community Providers

 for this insightful discussion. Before we end, I would like to get some closing thoughts or practice pearls you wish to share with your community colleagues from what we’ve discussed today.

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Panelists discuss optimizing treatment strategies for higher-risk myelofibrosis patients. They focus on managing thrombocytopenia, anemia, and ruxolitinib failure while exploring the role of JAK inhibitors and sequencing therapies.

Panelists discuss how frequently patients with newly diagnosed myelofibrosis present with moderate or severe thrombocytopenia or both anemia and thrombocytopenia. They discuss how these factors and other disease characteristics like spleen size and constitutional symptoms influence their treatment approach and selection of JAK inhibitors.

Clinical Perspectives: Firstline Treatment Landscape in Higher-Risk MF

Panelists discuss the latest data on pacritinib’s effects on anemia and bicytopenia, and share their treatment approaches for patients with myelofibrosis who present with both thrombocytopenia and anemia.

Tackling Complex Clinical Scenarios: MF Patients With Thrombocytopenia and Anemia

Panelists discuss how they define “ruxolitinib failure” and a suboptimal response, when they consider switching from first-line ruxolitinib, and how they differentiate between myelofibrosis-induced and JAK-induced cytopenias.

Challenges With Defining “Ruxolitinib Failure” or Suboptimal Response to Ruxolitinib in MF

Panelists discuss the patient and disease characteristics influencing the decision to dose-reduce ruxolitinib vs switching therapy. They share their typical sequencing approach after first-line ruxolitinib, including whether a washout period or overlap is required.

Clinical Insights on Managing Ruxolitinib Cytopenias: Patient-Focused Approach

Panelists share their closing thoughts and practice pearls, offering key insights and takeaways for community oncologists based on discussing treatment strategies in myelofibrosis.

Practice Takeaways: Treating MF Patients—Key Strategies for Community Providers

EP: 1.Clinical Perspectives: Firstline Treatment Landscape in Higher-Risk MF

EP: 2.Tackling Complex Clinical Scenarios: MF Patients With Thrombocytopenia and Anemia

EP: 3.Challenges With Defining “Ruxolitinib Failure” or Suboptimal Response to Ruxolitinib in MF

EP: 4.Clinical Insights on Managing Ruxolitinib Cytopenias: Patient-Focused Approach

EP: 5.Practice Takeaways: Treating MF Patients—Key Strategies for Community Providers

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