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Perioperative vorasidenib or ivosidenib demonstrated sustained clinical benefit in patients with predominantly non-enhancing IDH1-mutant diffuse glioma.

Perioperative Vorasidenib and Ivosidenib Remain Effective, Safe in IDH1+ Diffuse Glioma 

Mirdametinib led to sustained, significant, and clinically meaningful improvements in HRQOL in adults and children with NF1-PN.

Mirdametinib Improves HRQOL in Adult and Pediatric Patients With NF1-PN

Priya U. Kumthekar, MD, discusses the use of a novel diagnostic platform to detect CSF tumor cells in patients with leptomeningeal disease.
 

Dr Kumethaker on CSF Tumor Detection in Breast Cancer or NSCLC with Leptomeningeal Disease  

David Schiff, MD, discusses PFS and OS data for radiation with or without temozolomide in patients with grade II glioma.

Dr Schiff on PFS and OS Data With Temozolomide Plus Radiation in Grade II Glioma

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Megan Hollasch joined MJH Life Sciences in 2022 following graduation from the University of Massachusetts Amherst with majors in Communication and English, and a specialization in Literature as History. She produces and edits original content for the print publication 

, aiding in all aspects of the publication process, as well as content for OncLive.com.

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 in November 2021 as a senior editor and became the website's managing editor in October 2023. Before arriving at MJH Life Sciences, he spent nearly a decade covering professional and high school sports—including the New Jersey Devils and the NHL from 2016 to 2021—for The Star-Ledger and NJ.com. Email: chryan@onclive.com

Premal Thaker, MD, MS, highlights data seen with the IL-12 Immunotherapy IMNN-001 in the OVATION-2 trial and next steps with the agent in ovarian cancer. 

IMNN-001 Plus Chemo Data Highlight Potential to Fill Unmet Need in Ovarian Cancer

Caroline Seymour is your initial point of contact for the 

™. She joined the company in 2018 as an assistant editor, with expertise in video production and print/digital publication. Email: cseymour@onclive.com​ 

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First-line use of TTFields plus gemcitabine and nab-paclitaxel improved OS vs chemotherapy in unresectable, locally advanced pancreatic adenocarcinoma.

Tumor Treating Fields Plus Chemotherapy Improves OS in Unresectable Pancreatic Cancer

Ashling Wahner joined MJH Life Sciences in 2022. She produces 

, and helps ensure timely publication of news content and announcements from the FDA approval pipeline. She also attends conferences live and virtually to conduct video interviews and produce written coverage. Email: awahner@mjhlifesciences.com

In case you missed any, read a recap of every episode of OncLive On Air that aired in November 2024.  

Revisit Every OncLive On Air Episode From November 2024

Researchers at Moffitt Cancer Center published an article in Cancer Cell showing that necroptosis-mediated immune suppression occurs through release of IL-1α.

Moffitt Study Shows How Cancer Cell Death May Harm the Immune System and Promote Tumor Growth

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Novel Breakthroughs in Management of Pediatric Low-Grade Glioma (pLGG)

Clinical

Video Series

Clinical scenario 2 - BRAFV600E

Videos

Pediatric low-grade glioma specialists examine recent therapeutic advancements and their practical implications, presenting two real-world cases to demonstrate the integration of new data into clinical decision-making.

Key opinion leaders offer a comprehensive overview of pediatric low-grade glioma, encompassing its epidemiology, characteristic disease presentation, differentiation from adult manifestations, and impact on patients' quality of life.

Overview of pLGG presentation and categorization

Experts examine the molecular diversity of pediatric low-grade gliomas, exploring its significance for diagnostic approaches and therapeutic strategies.

Molecular Characterization of pLGG

The panel examines less prevalent molecular alterations in pediatric low-grade gliomas (pLGG), with a particular focus on BRAF mutations, discussing their characteristics and implications for patient care.

Less Common Molecular Alterations in pLGG and Testing Recommendations

The experts in pediatric low-grade gliomas (pLGG) delineate the standard of care for frontline treatment of tumors not harboring the BRAF V600E mutation, outlining current best practices and therapeutic approaches.

Standard of care for frontline treatment of non-V600E-specific pLGG tumors

The panel reviews ongoing clinical trials for non-BRAF V600E pediatric low-grade gliomas (pLGG), specifically highlighting the Phase III ACNS1831 and Phase III ACNS1833 studies, discussing their objectives, designs, and potential implications for future treatment strategies.

Ongoing clinical trials for frontline treatment of non-V600E-specific pLGG tumors

Current Treatment of Patients with NF1 pLGG

The panel explores the standard of care options tailored specifically for the frontline treatment of pediatric low-grade gliomas (pLGG) harboring the BRAF V600E mutation, discussing current best practices and targeted therapeutic approaches.

Standard of Care Pptions Specific for Frontline Treatment of BRAF V600E-Mutated pLGG

Treatment Considerations for Progressive pLGG

The panel of medical experts examines the roles of radiation therapy and targeted therapies in the management of progressive pediatric low-grade gliomas (pLGG).

Radiation and Targeted Therapies for Progressive pLGG

The panel reviews ongoing clinical trials aimed at expanding treatment options for progressive pediatric low-grade gliomas (pLGG), with a specific focus on the PNOC021, PBTC-055, and NF111 studies, discussing their objectives, design features, and potential impact on future treatment strategies.

The Role of Tovorafenib in Treatment of Progressive pLGG

Clinical Trials to Increase Treatment Options in the Progressive Setting

The panel examines a specific patient case, offering detailed insights into their decision-making process and treatment approaches for patients with pediatric low-grade gliomas (pLGG).

Clinical scenario 1 - BRAFKIAA-1549 fusion

The panel presents alternative treatment options and key considerations for the discussed clinical scenario, elaborating on the factors that influence their decision-making process.

Alternatives and Considerations for Clinical Scenario 1

The key opinion leaders analyze a second clinical scenario, focusing on a patient with a BRAF V600E mutation in their pediatric low-grade glioma (pLGG).

Clinical Scenario 2 - BRAFV600E

The panel of pediatric low-grade glioma (pLGG) experts delves into the potential adverse events associated with targeted therapies, outlining common reactions and their severity, while also sharing their strategies and best practices for toxicity management.

Potential Adverse Events With Targeted Therapies

The leaders in the pediatric low-grade glioma (pLGG) field offer their concluding insights and perspectives on the future of pLGG management.

Clinical Scenario 2 - BRAFV600E

EP: 1.Overview of pLGG presentation and categorization

EP: 2.Molecular Characterization of pLGG

EP: 3.Less Common Molecular Alterations in pLGG and Testing Recommendations

EP: 4.Standard of care for frontline treatment of non-V600E-specific pLGG tumors

EP: 5.Ongoing clinical trials for frontline treatment of non-V600E-specific pLGG tumors

EP: 6.Current Treatment of Patients with NF1 pLGG

EP: 7.Standard of Care Pptions Specific for Frontline Treatment of BRAF V600E-Mutated pLGG

EP: 8.Treatment Considerations for Progressive pLGG

EP: 9.Radiation and Targeted Therapies for Progressive pLGG

EP: 10.The Role of Tovorafenib in Treatment of Progressive pLGG

EP: 11.Clinical Trials to Increase Treatment Options in the Progressive Setting

EP: 12.Clinical scenario 1 - BRAFKIAA-1549 fusion

EP: 13.Alternatives and Considerations for Clinical Scenario 1

EP: 14.Clinical Scenario 2 - BRAFV600E

EP: 15.Potential Adverse Events With Targeted Therapies

EP: 16.Clinical Insights: Looking Forward for pLGG

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