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The neoadjuvant/adjuvant pembrolizumab and chemotherapy combination was approved by the FDA in October 2023 for use in this patient population.

Perioperative Pembrolizumab Regimen Upholds Survival Benefit in Resectable NSCLC

Zongertinib demonstrated durable efficacy in patients with pretreated advanced HER2-mutant non–small cell lung cancer.

Zongertinib Elicits Durable Responses in Pretreated Advanced HER2-Mutant NSCLC 

Second-line lenvatinib had clinically meaningful efficacy in patients with advanced HCC after progression on atezolizumab plus bevacizumab.

Lenvatinib Shows Efficacy in Advanced HCC Post-Progression on Atezolizumab/Bevacizumab

The phase 3 TROPiCS-04 study missed its primary end point of improved OS with sacituzumab govitecan vs chemotherapy in patients with urothelial cancer.

Sacituzumab Govitecan Does Not Significantly Improve OS in Pretreated Urothelial Carcinoma

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Articles

The FDA awards accelerated approval to encorafenib regimen in BRAF V600E+ CRC, ensartinib wins approval in ALK+ non–small cell lung cancer, and more.

The OncFive: Top Oncology Articles for the Week of 12/15


Gina Mauro is your lead editorial contact for 

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. Prior to joining MJH Life Sciences, she worked at Gannett as a full-time reporter with the Asbury Park Press. Email: gmauro@onclive.com 

 
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 in November 2021 as a senior editor and became the website's managing editor in October 2023. Before arriving at MJH Life Sciences, he spent nearly a decade covering professional and high school sports—including the New Jersey Devils and the NHL from 2016 to 2021—for The Star-Ledger and NJ.com. Email: chryan@onclive.com

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Adding dostarlimab to chemotherapy and niraparib maintenance improved progression-free survival in first-line advanced ovarian cancer.

Addition of Dostarlimab to Chemo and Niraparib Maintenance Boosts PFS in Advanced Ovarian Cancer

 as an assistant editor in October 2022. Leveraging an educational background in the life sciences and prior experience conducting interviews in a university setting, she plays a key role in shaping social media strategy, covering live conferences, and producing multimedia content for both print and digital platforms. Email: 

The addition of pegcrisantaspase to venetoclax may overcome resistance to prior BCL-2 inhibitor–based regimens for patients with relapsed/refractory AML. 

Venetoclax Plus PegC May Overcome Resistance to Prior BCL-2 Inhibitors in R/R AML 

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My Treatment Approach: Optimizing Treatment for Chronic GVHD

Video Series

Clinical

Differentiating Acute and Chronic Graft-vs-Host Disease

Video content above is prompted by the following:

Is the time of onset the main distinction between acute and chronic graft-vs-host disease (cGVHD), or it is symptoms at clinical presentations as well? Please elaborate on tissues impacted.

Videos

This educational program, led by experts Shernan Holtan, MD, and Haris Ali, MD, explores the latest strategies and emerging treatments for optimizing management of chronic graft-vs-host disease (cGVHD), including monitoring techniques, therapeutic options, and patient-reported outcomes.

After a brief introduction, Shernan Holtan, MD, and Haris Ali, MD, discuss the distinction between acute and chronic graft-vs-host disease. 

Medical experts discuss navigating chronic GVHD.

Navigating Chronic GVHD: Phases of Pathophysiology and Best Practices in Patient Monitoring

Medical experts discuss overall goals for cGVHD treatment as well as concerns with long-term corticosteroid use in treatment. 

Optimizing Chronic GVHD Therapy

Medical experts discuss criteria for switching GVHD treatments and how to choose between available treatment options. 

Navigating Treatment Decisions in Chronic GVHD

Medical experts discuss advanced therapies in cGVHD. 

Overview of Advanced Therapies in cGVHD

Medical experts discuss the data that led to belumosudil’s FDA approval. 

Overview of the ROCKstar Study

Medical experts discuss considerations for third-line treatment in chronic GVHD. 

Considerations for Third-Line Treatment in Chronic GVHD

Medical experts discuss treatment selection for a specific clinical scenario. 

Clinical Scenario: Treatment Selection in the third line and beyond in cGVHD

Medical experts discuss the recent updates presented at ASH 2023 and TANDEM 2024. 

Recent Updates: REACH3, ROCKstar, and RWD

Medical experts discuss the mechanism of action within axatilimab. 

AGAVE-201: Axatilimab for cGVHD

Medical experts discuss emerging trends in chronic GVHD treatment. 

Emerging Trends in Chronic GVHD: Promising Clinical Trials and the Future Treatment Landscape

Medical experts discuss the role of patient-reported outcomes in cGVHD. 

Clinical Impact of Patient-Reported Outcomes in cGVHD

Medical experts discuss multidisciplinary approaches to GVHD. 

Differentiating Acute and Chronic Graft-vs-Host Disease

EP: 1.Differentiating Acute and Chronic Graft-vs-Host Disease

EP: 2.Navigating Chronic GVHD: Phases of Pathophysiology and Best Practices in Patient Monitoring

EP: 3.Optimizing Chronic GVHD Therapy

EP: 4.Navigating Treatment Decisions in Chronic GVHD

EP: 5.Overview of Advanced Therapies in cGVHD

EP: 6.Overview of the ROCKstar Study

EP: 7.Considerations for Third-Line Treatment in Chronic GVHD

EP: 8.Clinical Scenario: Treatment Selection in the third line and beyond in cGVHD

EP: 9.Recent Updates: REACH3, ROCKstar, and RWD

EP: 10.AGAVE-201: Axatilimab for cGVHD

EP: 11.Emerging Trends in Chronic GVHD: Promising Clinical Trials and the Future Treatment Landscape

EP: 12.Clinical Impact of Patient-Reported Outcomes in cGVHD

EP: 13.Multidisciplinary Approaches to GVHD

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