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Opinion|Videos|November 12, 2024

Navigating treatment strategies for patients with multi-refractory CLL: CAR-T, ASCT, and PI3K Inhibitors

Author(s)Nitin Jain, MD, Joanna M. Rhodes, MD, MSCE

Panelists discuss how various additional treatment options for relapsed/refractory chronic lymphocytic leukemia (CLL) are considered, including CAR-T cell therapy, immunomodulatory drugs like lenalidomide, chemoimmunotherapy regimens, and other emerging therapies, highlighting their potential roles in the evolving treatment landscape.

Episodes in this series

EP. 1 The Current Treatment Landscape for R/R CLL

EP. 1 The Current Treatment Landscape for R/R CLL

EP. 2 Impact of Prior BTKi vs BCL2i Therapy on Treatment Decision-Making in CLL

EP. 2 Impact of Prior BTKi vs BCL2i Therapy on Treatment Decision-Making in CLL

EP. 3 Key Patient-Specific Factors Guiding Treatment Selection in CLL

EP. 3 Key Patient-Specific Factors Guiding Treatment Selection in CLL

EP. 4 Tailoring Treatment Approaches for Rapid vs. Slow Disease Progression in CLL

EP. 4 Tailoring Treatment Approaches for Rapid vs. Slow Disease Progression in CLL

EP. 5 Assessing Resistance to First-Line BTK Inhibitor Therapy: The Emergine Role of Testing in CLL

EP. 5 Assessing Resistance to First-Line BTK Inhibitor Therapy: The Emergine Role of Testing in CLL

EP. 6 Pirtobrutinib in the Management of R/R CLL: Updates from the BRUIN Trial

EP. 6 Pirtobrutinib in the Management of R/R CLL: Updates from the BRUIN Trial

EP. 7 Application of Pirtobrutinib in R/R CLL: Expert Perspectives

EP. 7 Application of Pirtobrutinib in R/R CLL: Expert Perspectives

$EP. 8 Influence of TLS Risk and Patient Preferences on Treatment Selection in Relapsed/Refractory CLL$

EP. 8 Influence of TLS Risk and Patient Preferences on Treatment Selection in Relapsed/Refractory CLL

$EP. 9 Navigating treatment strategies for patients with multi-refractory CLL: CAR-T, ASCT, and PI3K Inhibitors$

EP. 9 Navigating treatment strategies for patients with multi-refractory CLL: CAR-T, ASCT, and PI3K Inhibitors

EP. 10 Sequencing and Combination Strategies with Pirtobrutinib and CAR-T Therapy in R/R CLL

EP. 10 Sequencing and Combination Strategies with Pirtobrutinib and CAR-T Therapy in R/R CLL

$EP. 11 Treatment Sequencing in Relapsed/Refractory CLL: Key Factors Influencing Decision-Making$

EP. 11 Treatment Sequencing in Relapsed/Refractory CLL: Key Factors Influencing Decision-Making

EP. 12 Emerging role of doublet triplet therapies in R/R CLL: Expert Perspectives

EP. 12 Emerging role of doublet triplet therapies in R/R CLL: Expert Perspectives

EP. 13 The Impact of Emerging Resistance Patterns on Treatment Sequencing in R/R CLL

EP. 13 The Impact of Emerging Resistance Patterns on Treatment Sequencing in R/R CLL

$EP. 14 Multidisciplinary Approach to Managing Treatment for Relapsed/Refractory CLL$

EP. 14 Multidisciplinary Approach to Managing Treatment for Relapsed/Refractory CLL

Video content above is prompted by the following:

Briefly mention additional treatment options in R/R CLL:
- CAR-T
- Duvelisib
- Idelalisib ± Rituximab
- Lenalidomide ± Rituximab
- FCR/BR (if no TP53 or del(17p))
- HSCT
- Others?

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