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Opinion|Videos|June 25, 2024

Prevalence and Testing Strategies for ESR1

Author(s)Virginia G. Kaklamani, MD, DSc, Heather McArthur, MD, MPH

Virginia Kaklamani, MD, DSc, and Heather McArthur, MD, explore the clinical significance of *ESR1* mutations in HR+/HER2- metastatic breast cancer patients, including their impact on disease prognosis, treatment outcomes, and the increasing prevalence of these mutations with each line of endocrine therapy, ultimately informing their therapeutic approach.

Episodes in this series

2 KOLs are featured in this program.

EP. 1 Prevalence and Testing Strategies for ESR1

2 KOLs are featured in this program.

EP. 2 Evolution of Testing Strategies for ESR1

2 KOLs are featured in this program.

EP. 3 Dynamics of ESR1 Alterations and Serial Liquid Biopsies

2 KOLs are featured in this program.

EP. 4 Case Presentation 1: PIK3CA Mutation With ESR1 Mutations

2 KOLs are featured in this program.

EP. 5 EMERALD Study Design and Results for Elacestrant

2 KOLs are featured in this program.

EP. 6 Evolving Best Practices for ESR1 Testing

2 KOLs are featured in this program.

EP. 7 Case Presentation 2: Co-mutations in ESR1 and PIK3CA

2 KOLs are featured in this program.

EP. 8 PIK3CA Mutations and Delivering PI3K Inhibitors

2 KOLs are featured in this program.

EP. 9 PostMONARCH: Dissecting Data on Sequential CDK 4/6 Inhibitors

2 KOLs are featured in this program.

EP. 10 Combinations and Treatment Sequence Strategies in Breast Cancer

2 KOLs are featured in this program.

EP. 11 Future Directions and Unmet Needs in HR+ Breast Cancer

2 KOLs are featured in this program.

EP. 12 Looking Ahead: Expert Future Perspectives in HR+ Breast Cancer

What are the clinical implications of ESR1 mutations for disease prognosis and treatment outcomes in HR+/HER2- mBC patients?
- How does the increasing prevalence of ESR1 mutations with each line of endocrine therapy inform your treatment approach and decision-making process?

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