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Paolo Caimi, MD, discusses the rationale behind evaluating LMY-920, a novel BAFF CAR T-cell therapy, in relapsed/refractory non-Hodgkin lymphoma.

Dr Caimi on Early Data for LMY-920 in R/R B-Cell NHL

David H. Aggen, MD, PhD, details the evolving landscape of treating patients with urothelial carcinoma.

Navigating a “Sea Change” in Frontline Urothelial Carcinoma Treatment

Jennifer Scalici, MD, discusses data for IMNN-001plus chemotherapy in advanced ovarian cancer.

Dr Scalici on Data for IMNN-001 Plus SOC Chemotherapy in Advanced Ovarian Cancer

Steven H. Lin, MD, PhD, discusses the safety of NKTR-255 in enhancing immune recovery post-chemoradiation in locally advanced NSCLC.

Dr Lin on the Safety of NKTR-255 in Enhancing Immune Recovery Post-Chemoradiation in Locally Advanced NSCLC

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PYX-201 produced responses in heavily pretreated head and neck squamous cell carcinoma and other solid tumors. 

PYX-201 Generates Responses in Pretreated Advanced HNSCC and Other Solid Tumors

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Sandy Srinivas, MD, details updates from 2024 in the kidney and prostate cancer NCCN guidelines and agents/trials to look forward to in 2025. 

Kidney Cancer NCCN Guidelines Receive Major Updates, Prostate Cancer Adds Targeted Agents 

The FDA has granted accelerated approval to zanidatamab for pretreated, advanced HER2-positive biliary tract cancer.

FDA Approves Zanidatamab for Previously Treated, Unresectable or Metastatic HER2+ Biliary Tract Cancer

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Osimertinib has been recommended for approval in patients with locally advanced, unresectable, EGFR-mutant NSCLC after chemoradiation.

Osimertinib Approaches EU Approval in Locally Advanced EGFR+ NSCLC After Chemoradiation

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Updates on HER2-Directed ADCs Across Solid Tumors

Video Series

Overcoming Challenges of Testing for HER2-low Across Solid Tumor Types

Video content above is prompted by the following:

Where could T-DXd fit into the current treatment armamentarium? 

Videos

Vijayakrishna Gadi, MD, PhD, sets the stage for a discussion around HER2-directed ADCs in the solid tumor space.

Dr Gadi leads a discussion surrounding HER2 mutation and overexpression across various cancer types.

Assessing HER2 Status Across Tumor Types

Dr Gadi introduces treatment and trial data targeting care for patients diagnosed with HER2+ breast cancer.

ADCs Targeting HER2+ Breast Cancer

Dr Campos discusses the potential for T-DXd in other gynecologic cancers and offers an overview of  results from the DESTINY-PanTumor02 trial.

ADCs Targeting HER2+ Gynecologic Cancers

Dr  Gadi leads a discussion on recent data on the treatment of HER2-low tumors, including ASCO updates on the DESTINY-Breast06 trial.

Emerging Data from ASCO 2024 in HER2-low: DESTINY-Breast06

Dr Parikh discusses the history of ADCs for treating GI cancers with a focus on the data for T-DXd and its role in treating these cancers.

ADCs Targeting GI Cancers

Dr Garon shares insights on the role of ADCs for the treatment of HER2+ lung cancer.

ADCs Targeting HER2+ Lung Cancer

A panel of experts discuss where HER2-directed ADCs antibody-drug conjugates fit into the overall treatment paradigm. 

Impact of ADCs on Brain Metastases

A panel of experts discuss if there is a role for HER2-directed ADCs antibody-drug conjugates in GU genitourinary cancers

ADCs Targeting HER2+ GU Cancers

A panel of experts discuss the challenges of testing for HER2-low access  solid tumor types. 

Vijayakrishna Gadi, MD, PhD, discusses the role of antibody-drug conjugates in a curative setting.

The Potential Role for HER2-Targeted ADCs in Earlier Treatment Lines

Vijayakrishna Gadi, MD, PhD, discusses the risk of ILD and pneumonitis from ADCs.

Managing ILD and Pneumonitis Risk From ADCs

Vijayakrishna Gadi, MD, PhD, discusses short-term and long-term treatments with ADCs.

Managing Toxicities in Short- and Long-Term Treatment with ADCs

A panel of experts discuss hematologic adverse events associated with antibody-drug conjugate therapies.

Managing Hematologic AEs Associated with ADC Treatments

Experts provide clinical insights on the management of emetogenicity in patients receiving antibody-drug conjugates.

Management of Emetogenicity of Antibody-Drug Conjugates

Expert clinicians offer strategic guidance on optimal sequencing of antibody-drug conjugates (ADCs) in treatment protocols.

ADC Sequencing

Key opinion leaders examine promising antibody-drug conjugates (ADCs) in the pharmaceutical development pipeline.

Emerging ADCs in Development

Ronan Kelly, MD, MBA, offers insights on trastuzumab deruxtecan approval as tumor-agnostic HER2-directed therapy.

Insights on T-DXd Approval as Tumor-Agnostic HER2-Directed Therapy

Ronan Kelly, MD, MBA, offers insights on the future for HER2-directed antibody-drug conjugates.

The Future for HER2-Directed ADCs

Experts discuss key takeaways and closing thoughts on antibody-drug conjugates (ADCs) in cancer treatment.

Overcoming Challenges of Testing for HER2-low Across Solid Tumor Types

EP: 1.Assessing HER2 Status Across Tumor Types

EP: 2.ADCs Targeting HER2+ Breast Cancer

EP: 3.ADCs Targeting HER2+ Gynecologic Cancers

EP: 4.Emerging Data from ASCO 2024 in HER2-low: DESTINY-Breast06

EP: 5.ADCs Targeting GI Cancers

EP: 6.ADCs Targeting HER2+ Lung Cancer

EP: 7.Impact of ADCs on Brain Metastases

EP: 8.ADCs Targeting HER2+ GU Cancers

EP: 9.Overcoming Challenges of Testing for HER2-low Across Solid Tumor Types

EP: 10.The Potential Role for HER2-Targeted ADCs in Earlier Treatment Lines

EP: 11.Managing ILD and Pneumonitis Risk From ADCs

EP: 12.Managing Toxicities in Short- and Long-Term Treatment with ADCs

EP: 13.Managing Hematologic AEs Associated with ADC Treatments

EP: 14.Management of Emetogenicity of Antibody-Drug Conjugates

EP: 15.ADC Sequencing

EP: 16.Emerging ADCs in Development

EP: 17.Insights on T-DXd Approval as Tumor-Agnostic HER2-Directed Therapy

EP: 18.The Future for HER2-Directed ADCs

EP: 19.Key Takeaways and Closing Thoughts on ADCs

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