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Paolo Caimi, MD, discusses the rationale behind evaluating LMY-920, a novel BAFF CAR T-cell therapy, in relapsed/refractory non-Hodgkin lymphoma.

Dr Caimi on Early Data for LMY-920 in R/R B-Cell NHL

David H. Aggen, MD, PhD, details the evolving landscape of treating patients with urothelial carcinoma.

Navigating a “Sea Change” in Frontline Urothelial Carcinoma Treatment

Jennifer Scalici, MD, discusses data for IMNN-001plus chemotherapy in advanced ovarian cancer.

Dr Scalici on Data for IMNN-001 Plus SOC Chemotherapy in Advanced Ovarian Cancer

Steven H. Lin, MD, PhD, discusses the safety of NKTR-255 in enhancing immune recovery post-chemoradiation in locally advanced NSCLC.

Dr Lin on the Safety of NKTR-255 in Enhancing Immune Recovery Post-Chemoradiation in Locally Advanced NSCLC

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David R. Oveisi, MD, discusses how the expanded indications for ide-cel and cilta-cel are affecting treatment decision-making in multiple myeloma.

Expanded Indications for CAR T-Cell Therapies Shepard in New Era of Myeloma Care

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Alberto Montero, MD, MBA, CPHQ, discusses the potential role for STX-478 in PIK3CA-mutant breast and gynecologic cancers. 

STK-478 May Be an Effective, Tolerable Treatment Alternative in PIK3CA-Mutant Breast and Gynecologic Cancers

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Zorifertinib has received NMPA approval in the first line for EGFR-mutant advanced or metastatic non–small cell lung cancer displaying CNS metastases.

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The FDA has approved revised drug labeling for fludarabine phosphate under Project Renewal.

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Updates on HER2-Directed ADCs Across Solid Tumors

Video Series

The Potential Role for HER2-Targeted ADCs in Earlier Treatment Lines

Video content above is prompted by the following:

A discussion surrounding earlier treatment lines involving HER2-targeted ADCs.

Videos

Vijayakrishna Gadi, MD, PhD, sets the stage for a discussion around HER2-directed ADCs in the solid tumor space.

Dr Gadi leads a discussion surrounding HER2 mutation and overexpression across various cancer types.

Assessing HER2 Status Across Tumor Types

Dr Gadi introduces treatment and trial data targeting care for patients diagnosed with HER2+ breast cancer.

ADCs Targeting HER2+ Breast Cancer

Dr Campos discusses the potential for T-DXd in other gynecologic cancers and offers an overview of  results from the DESTINY-PanTumor02 trial.

ADCs Targeting HER2+ Gynecologic Cancers

Dr  Gadi leads a discussion on recent data on the treatment of HER2-low tumors, including ASCO updates on the DESTINY-Breast06 trial.

Emerging Data from ASCO 2024 in HER2-low: DESTINY-Breast06

Dr Parikh discusses the history of ADCs for treating GI cancers with a focus on the data for T-DXd and its role in treating these cancers.

ADCs Targeting GI Cancers

Dr Garon shares insights on the role of ADCs for the treatment of HER2+ lung cancer.

ADCs Targeting HER2+ Lung Cancer

A panel of experts discuss where HER2-directed ADCs antibody-drug conjugates fit into the overall treatment paradigm. 

Impact of ADCs on Brain Metastases

A panel of experts discuss if there is a role for HER2-directed ADCs antibody-drug conjugates in GU genitourinary cancers

ADCs Targeting HER2+ GU Cancers

A panel of experts discuss the challenges of testing for HER2-low access  solid tumor types. 

Overcoming Challenges of Testing for HER2-low Across Solid Tumor Types

Vijayakrishna Gadi, MD, PhD, discusses the role of antibody-drug conjugates in a curative setting.

Vijayakrishna Gadi, MD, PhD, discusses the risk of ILD and pneumonitis from ADCs.

Managing ILD and Pneumonitis Risk From ADCs

Vijayakrishna Gadi, MD, PhD, discusses short-term and long-term treatments with ADCs.

Managing Toxicities in Short- and Long-Term Treatment with ADCs

A panel of experts discuss hematologic adverse events associated with antibody-drug conjugate therapies.

Managing Hematologic AEs Associated with ADC Treatments

Experts provide clinical insights on the management of emetogenicity in patients receiving antibody-drug conjugates.

Management of Emetogenicity of Antibody-Drug Conjugates

Expert clinicians offer strategic guidance on optimal sequencing of antibody-drug conjugates (ADCs) in treatment protocols.

ADC Sequencing

Key opinion leaders examine promising antibody-drug conjugates (ADCs) in the pharmaceutical development pipeline.

Emerging ADCs in Development

Ronan Kelly, MD, MBA, offers insights on trastuzumab deruxtecan approval as tumor-agnostic HER2-directed therapy.

Insights on T-DXd Approval as Tumor-Agnostic HER2-Directed Therapy

Ronan Kelly, MD, MBA, offers insights on the future for HER2-directed antibody-drug conjugates.

The Future for HER2-Directed ADCs

Experts discuss key takeaways and closing thoughts on antibody-drug conjugates (ADCs) in cancer treatment.

The Potential Role for HER2-Targeted ADCs in Earlier Treatment Lines

EP: 1.Assessing HER2 Status Across Tumor Types

EP: 2.ADCs Targeting HER2+ Breast Cancer

EP: 3.ADCs Targeting HER2+ Gynecologic Cancers

EP: 4.Emerging Data from ASCO 2024 in HER2-low: DESTINY-Breast06

EP: 5.ADCs Targeting GI Cancers

EP: 6.ADCs Targeting HER2+ Lung Cancer

EP: 7.Impact of ADCs on Brain Metastases

EP: 8.ADCs Targeting HER2+ GU Cancers

EP: 9.Overcoming Challenges of Testing for HER2-low Across Solid Tumor Types

EP: 10.The Potential Role for HER2-Targeted ADCs in Earlier Treatment Lines

EP: 11.Managing ILD and Pneumonitis Risk From ADCs

EP: 12.Managing Toxicities in Short- and Long-Term Treatment with ADCs

EP: 13.Managing Hematologic AEs Associated with ADC Treatments

EP: 14.Management of Emetogenicity of Antibody-Drug Conjugates

EP: 15.ADC Sequencing

EP: 16.Emerging ADCs in Development

EP: 17.Insights on T-DXd Approval as Tumor-Agnostic HER2-Directed Therapy

EP: 18.The Future for HER2-Directed ADCs

EP: 19.Key Takeaways and Closing Thoughts on ADCs

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