Real-World Evidence and Emerging Therapies in Lower-Risk MDS: Insights from EHA 2024

Author(s):

Guillermo Garcia-Manero, MD,Rami Komrokji, MD

Key opinion leaders (KOLs) examine real-world evidence and draw on their clinical experiences to inform their practice, discussing real-world dose escalations and key insights gained from practical application.

EP: 1.Navigating Myelodysplastic Syndromes: Updates to WHO & ICC Guidelines, IPSS-M, and Risk Stratification

EP: 2.Dr Oliva on Addressing Challenges in Treating Lower-Risk MDS 

EP: 3.Frontline Therapy for Lower-Risk MDS: Global Perspectives and Treatment Selection Strategies

EP: 4.Review of the COMMANDS Trial

EP: 5.Perceptions of the EHA 2024 Full Analysis of the COMMANDs Trial

EP: 6.Clinical Implications of COMMANDS Trial in Clinical Practice

EP: 7.Treatment Decision-Making Based on the COMMANDS Trials

EP: 8.Exploring Biomarker Analysis, Real-World Data, and Quality of Life in LR-MDS: Insights from EHA 2024

EP: 9.Dr.'s Cluzeau and Komrokji on Utilization Patterns of luspatercept in LR-MDS EHA 2024 Data

EP: 10.Safety Profile of Available Frontline Treatments LR-MDS

EP: 11.1L treatment of lower-risk MDS beyond luspatercept

EP: 12.Sequencing Second-Line Treatments for LR-MDS

EP: 13.Perspectives of IMerge Study

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EP: 14.Real-World Evidence and Emerging Therapies in Lower-Risk MDS: Insights from EHA 2024

EP: 15.EHA 2024 Future Directions in Lower-Risk MDS Treatment: Emerging Data, Approvals, and Guideline Updates

EP: 16.Final Thoughts on EHA 2024 Data for Lower-Risk MDS

Focusing on real-world evidence (RWE), how do outcomes compare what’s seen in practice and how does that impact your choice of therapy?
1. Real-world dose escalation and outcomes of luspatercept across all LOTs (Patel K, et al. EHA 2024. Abstract P768.)
2. IMerge study, PROs in heavily pre-treated patients with LR-MDS: Sekeres MA, et al. Blood. 2023; 142 (suppl 1):6479.
3. Real World Data Replicates Medalist Study Results (Komrokji RS et al. Blood 2022)
Can each of you share any key takeaways or additional data updates surrounding lower-risk MDS presented at EHA 2024? (if time permits)
Let’s discuss novel agents and/or combination strategies in LR-MDS through ongoing research that may shape the future treatment landscape.
1. Luspatercept plus erythropoietin in LR-MDS: Jonasova A, et al. EHA 2024. Abstract P1886.
2. Luspatercept plus ESA combinations in LR-MDS: Komrokji RS, et al. Blood Adv. 2023.
3. Ph 2 study, elritercept (KER-050): Díez Campelo M, et al. EHA 2024. Abstract S183.