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Opinion|Videos|August 2, 2024

Sequencing Second-Line Treatments for LR-MDS

Author(s)Guillermo Garcia-Manero, MD, Rami Komrokji, MD, Esther Natalie Oliva, MD

Medical experts discuss sequencing strategies for second-line and later treatments in lower-risk myelodysplastic syndromes, examining how recent data, including insights from the MEDALIST trial, influence treatment selection and sequencing decisions.

Episodes in this series

5 KOLs are featured in this program

EP. 1 Navigating Myelodysplastic Syndromes: Updates to WHO & ICC Guidelines, IPSS-M, and Risk Stratification

5 KOLs are featured in this program

EP. 2 Dr Oliva on Addressing Challenges in Treating Lower-Risk MDS 

5 KOLs are featured in this program

EP. 3 Frontline Therapy for Lower-Risk MDS: Global Perspectives and Treatment Selection Strategies

5 KOLs are featured in this program

EP. 4 Review of the COMMANDS Trial

5 KOLs are featured in this program

EP. 5 Perceptions of the EHA 2024 Full Analysis of the COMMANDs Trial

5 KOLs are featured in this program

EP. 6 Clinical Implications of COMMANDS Trial in Clinical Practice

5 KOLs are featured in this program

EP. 7 Treatment Decision-Making Based on the COMMANDS Trials

5 KOLs are featured in this program

EP. 8 Exploring Biomarker Analysis, Real-World Data, and Quality of Life in LR-MDS: Insights from EHA 2024

5 KOLs are featured in this program

EP. 9 Dr.'s Cluzeau and Komrokji on Utilization Patterns of luspatercept in LR-MDS EHA 2024 Data

5 KOLs are featured in this program

EP. 10 Safety Profile of Available Frontline Treatments LR-MDS

5 KOLs are featured in this program

EP. 11 1L treatment of lower-risk MDS beyond luspatercept

5 KOLs are featured in this program

EP. 12 Sequencing Second-Line Treatments for LR-MDS

5 KOLs are featured in this program

EP. 13 Perspectives of IMerge Study

5 KOLs are featured in this program

EP. 14 Real-World Evidence and Emerging Therapies in Lower-Risk MDS: Insights from EHA 2024

5 KOLs are featured in this program

EP. 15 EHA 2024 Future Directions in Lower-Risk MDS Treatment: Emerging Data, Approvals, and Guideline Updates

5 KOLs are featured in this program

EP. 16 Final Thoughts on EHA 2024 Data for Lower-Risk MDS

Let’s explore sequencing strategies for lower-risk MDS in the 2L setting and beyond. Discuss how new data and other considerations impact treatment selection and sequencing.
Dr Komrokji: How do you approach treating patients with luspatercept from based on data from the MEDALIST trial? (Santini V, et al. ASH 2023. Abstract 915)
1. What is the impact of fatigue events on overall treatment outcomes in patients treated with luspatercept for LR-MDS?
Dr. Thomas Cluzeau: Based on the results from the MEDALIST trial, how would you approach dose escalation for 2L treatment of luspatercept in patients with LR-MDS? (Platzbecker U et al. Blood 2022)

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