Opinion
Video
Review of the COMMANDS Trial
Author(s):
The experts examine the COMMANDS trial, which assessed luspatercept in lower-risk myelodysplastic syndrome patients, detailing the trial's design, participant groups, and key outcome measures.
EP: 1.Navigating Myelodysplastic Syndromes: Updates to WHO & ICC Guidelines, IPSS-M, and Risk Stratification
EP: 2.Dr Oliva on Addressing Challenges in Treating Lower-Risk MDS
EP: 3.Frontline Therapy for Lower-Risk MDS: Global Perspectives and Treatment Selection Strategies
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EP: 4.Review of the COMMANDS Trial
EP: 5.Perceptions of the EHA 2024 Full Analysis of the COMMANDs Trial
EP: 6.Clinical Implications of COMMANDS Trial in Clinical Practice
EP: 7.Treatment Decision-Making Based on the COMMANDS Trials
EP: 8.Exploring Biomarker Analysis, Real-World Data, and Quality of Life in LR-MDS: Insights from EHA 2024
EP: 9.Dr.'s Cluzeau and Komrokji on Utilization Patterns of luspatercept in LR-MDS EHA 2024 Data
EP: 10.Safety Profile of Available Frontline Treatments LR-MDS
EP: 11.1L treatment of lower-risk MDS beyond luspatercept
EP: 12.Sequencing Second-Line Treatments for LR-MDS
EP: 13.Perspectives of IMerge Study
EP: 14.Real-World Evidence and Emerging Therapies in Lower-Risk MDS: Insights from EHA 2024
EP: 15.EHA 2024 Future Directions in Lower-Risk MDS Treatment: Emerging Data, Approvals, and Guideline Updates
EP: 16.Final Thoughts on EHA 2024 Data for Lower-Risk MDS
- Dr Garcia-Manero: Briefly summarize the COMMANDS trial, evaluating luspatercept in patients with lower-risk MDS (Platzbecker U et al. Lancet Onco 2023).
- Briefly comment on the study design, patient population, and primary/secondary endpoints.
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