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Opinion|Videos|August 10, 2024

Perspectives of IMerge Study

Author(s)Guillermo Garcia-Manero, MD, Rami Komrokji, MD, Esther Natalie Oliva, MD

Medical professionals deliberate on patient selection criteria for second-line imetelstat treatment in lower-risk myelodysplastic syndromes, incorporating findings from the IMerge study into their considerations.

Episodes in this series

5 KOLs are featured in this program

EP. 1 Navigating Myelodysplastic Syndromes: Updates to WHO & ICC Guidelines, IPSS-M, and Risk Stratification

5 KOLs are featured in this program

EP. 2 Dr Oliva on Addressing Challenges in Treating Lower-Risk MDS 

5 KOLs are featured in this program

EP. 3 Frontline Therapy for Lower-Risk MDS: Global Perspectives and Treatment Selection Strategies

5 KOLs are featured in this program

EP. 4 Review of the COMMANDS Trial

5 KOLs are featured in this program

EP. 5 Perceptions of the EHA 2024 Full Analysis of the COMMANDs Trial

5 KOLs are featured in this program

EP. 6 Clinical Implications of COMMANDS Trial in Clinical Practice

5 KOLs are featured in this program

EP. 7 Treatment Decision-Making Based on the COMMANDS Trials

5 KOLs are featured in this program

EP. 8 Exploring Biomarker Analysis, Real-World Data, and Quality of Life in LR-MDS: Insights from EHA 2024

5 KOLs are featured in this program

EP. 9 Dr.'s Cluzeau and Komrokji on Utilization Patterns of luspatercept in LR-MDS EHA 2024 Data

5 KOLs are featured in this program

EP. 10 Safety Profile of Available Frontline Treatments LR-MDS

5 KOLs are featured in this program

EP. 11 1L treatment of lower-risk MDS beyond luspatercept

5 KOLs are featured in this program

EP. 12 Sequencing Second-Line Treatments for LR-MDS

5 KOLs are featured in this program

EP. 13 Perspectives of IMerge Study

5 KOLs are featured in this program

EP. 14 Real-World Evidence and Emerging Therapies in Lower-Risk MDS: Insights from EHA 2024

5 KOLs are featured in this program

EP. 15 EHA 2024 Future Directions in Lower-Risk MDS Treatment: Emerging Data, Approvals, and Guideline Updates

5 KOLs are featured in this program

EP. 16 Final Thoughts on EHA 2024 Data for Lower-Risk MDS

Please comment on which patients you would consider 2L imetelstat for patients with LR-MDS.
1. Please provide a summary of the IMerge study, evaluating imetelstat in patients that R/R to ESAs in LR-MDS. (Platzbecker U, Santini V, Fenaux P, et al. Lancet. 2024;403(10423):249-260.)
2. Dr Komrokji: How does the latest follow up from the IMergestudy support the use of imetelstat in patients with LR-MDS?

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